The Inactivation of Intrinsic Antibiotic Resistance Determinants Widens the Mutant Selection Window for Quinolones in Stenotrophomonas maltophilia

被引：9
|
作者：
Garcia-Leon, Guillermo [1 ]
Sanchez, Maria B. [1 ]
Martinez, Jose L. [1 ]
机构：
[1] CSIC, Dept Biotecnol Microbiana, Ctr Nacl Biotecnol, Madrid, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 12期
关键词：
MULTIDRUG EFFLUX PUMP; SMEDEF; CIPROFLOXACIN; RESISTOME; GENOME;
D O I：
10.1128/AAC.01558-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF and SmQnr presented levels of susceptibility similar to those of the wild-type strain. This indicates that inactivation of intrinsic resistance determinants might increase the chances for selecting resistant mutants at low antibiotic concentrations.
引用
收藏
页码：6397 / 6399
页数：3
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