Thermoresponsive Aggregation Behavior of Triterpene-Poly(ethylene oxide) Conjugates in Water

被引：11
|
作者：
Zhao, Junpeng [1 ]
Jeromenok, Jekaterina [1 ]
Weber, Jens [1 ]
Schlaad, Helmut [1 ]
机构：
[1] Max Planck Inst Colloids & Interfaces, Dept Colloid Chem, D-14424 Potsdam, Germany
来源：
MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 09期
关键词：
aggregation; bioconjugate; poly(ethylene oxide); terpene; thermoresponsive; LIQUID-CRYSTALLINE POLYMER; BLOCK-COPOLYMERS; NONIONIC SURFACTANT; SELF-ASSOCIATION; CHOLESTEROL; MICELLES; DESIGN; TRANSITION; HYDROGELS; CORE;
D O I：
10.1002/mabi.201200131
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioconjugate amphiphiles comprising triterpene and poly(ethylene oxide) (PEO) were studied according to their thermoresponsive aggregation behavior (LCST) in water. Cholesteryl-PEO (CE) and betulinyl-PEO (BE) comprising <70 wt% PEO precipitated from water upon heating. CE, but not BE, solutions contained nanoscopic aggregates at room temperature causing different thermoprecipitation behaviors. Solutions containing 5?wt% solutions of BE with short PEO chains demonstrated dual thermoresponsive behavior, precipitating at high temperature and forming hydrogel at low temperature. A BE multiblock copolymer was found to form large aggregates, presumably vesicles, in water. Results suggest that the solution properties of triterpenePEO amphiphiles can be controlled by the chemical composition and structure.
引用
收藏
页码：1272 / 1278
页数：7
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