CAR cell design strategies in solid tumors

被引：5

作者：

Wang, Lu ^{[1
]}

Chen, Xinyi ^{[1
]}

Zhang, Lu ^{[1
]}

Niu, Boning ^{[2
]}

Li, Long ^{[1
]}

Sun, Yinan ^{[3
]}

Yuan, Xianglin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Jie Fang Rd 1095, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hangkong Rd 13, Wuhan, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Cardiol, Jie Fang Rd 1095, Wuhan, Hubei, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 113卷

关键词：

Chimeric antigen receptor; Design strategy; Solid tumors; Cytokine release syndrome; DELTA T-CELLS; CANCER; THERAPY; IMMUNOTHERAPY; RECEPTORS; RECOGNITION; CYTOKINE; FUTURE;

D O I：

10.1016/j.intimp.2022.109345

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to chimeric antigen receptor (CAR)-alpha beta T-cell therapy, CAR-NK, CAR-NKT, CAR-M and CAR-gamma delta T-cell therapy have gradually been applied to the treatment of solid tumors. Compared to hematological tumors, solid tumors have the characteristics of strong tumor heterogeneity, limited target antigen selection, and low T-cell infiltration to build immunosuppressive tumor microenvironment. These features would present great obstacles to CAR cell therapy. This paper comprehensively analyzed the application of different CAR cells to solid tumors and summarized the design principles of different CAR cells to provide the direction for the development of CAR cell therapy in solid tumors.

引用

页数：9

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