Pontin and Reptin, two related ATPases with multiple roles in cancer

被引：82

作者：

Huber, Otmar ^{[2
]}

Menard, Ludovic ^{[1
]}

Haurie, Valerie ^{[1
]}

Nicou, Alexandra ^{[1
]}

Taras, Daniele ^{[1
]}

Rosenbaum, Jean ^{[1
]}

机构：

[1] Univ Bordeaux 2, INSERM, U889, F-33076 Bordeaux, France

[2] Charite Univ Med Berlin, Dept Lab Med & Pathobiochem, D-13353 Berlin, Germany

来源：

CANCER RESEARCH | 2008年 / 68卷 / 17期

关键词：

D O I：

10.1158/0008-5472.CAN-08-0547

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies in model organisms or cultured human cells suggest. potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get. insight into the role of Pontin and Reptin in human cancers.

引用

页码：6873 / 6876

页数：4

共 26 条

[1] Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity [J].

Bauer, A ;

Chauvet, S ;

Huber, O ;

Usseglio, F ;

Rothbächer, U ;

Aragnol, D ;

Kemler, R ;

Pradel, J .

EMBO JOURNAL, 2000, 19 (22) :6121-6130

[2] Pontin52, an interacticon partner of β-catenin, binds to the TATA box binding protein [J].

Bauer, A ;

Huber, O ;

Kemler, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14787-14792

[3] Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development [J].

Bellosta, P ;

Hulf, T ;

Diop, SB ;

Usseglio, F ;

Pradel, J ;

Aragnol, D ;

Gallant, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11799-11804

[4] Proteomic analysis of differentially expressed proteins in hepatocellular carcinoma developed in patients with chronic viral hepatitis C [J].

Blanc, JF ;

Lalanne, C ;

Plomion, C ;

Schmitter, JM ;

Bathany, K ;

Gion, JM ;

Bioulac-Sage, P ;

Balabaud, C ;

Bonneu, M ;

Rosenbaum, J .

PROTEOMICS, 2005, 5 (14) :3778-3789

[5] The p400 E1A-associated protein is a novel component of the p53→p21 senescence pathway [J].

Chan, HM ;

Narita, M ;

Lowe, SW ;

Livingstone, DM .

GENES & DEVELOPMENT, 2005, 19 (02) :196-201

[6] TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage [J].

Cho, SG ;

Bhoumik, A ;

Broday, L ;

Ivanov, V ;

Rosenstein, B ;

Ronai, Z .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (24) :8398-8413

[7] Chromosomal aberrations and gene expression profiles in non-small cell lung cancer [J].

Dehan, E. ;

Ben-Dor, A. ;

Liao, W. ;

Lipson, D. ;

Frimer, H. ;

Rienstein, S. ;

Simansky, D. ;

Krupsky, M. ;

Yaron, P. ;

Friedman, E. ;

Rechavi, G. ;

Perlman, M. ;

Aviram-Goldring, A. ;

Izraeli, S. ;

Bittner, M. ;

Yakhini, Z. ;

Kaminski, N. .

LUNG CANCER, 2007, 56 (02) :175-184

[8] TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis [J].

Dugan, KA ;

Wood, MA ;

Cole, MD .

ONCOGENE, 2002, 21 (38) :5835-5843

[9] Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1 [J].

Etard, C ;

Gradl, D ;

Kunz, M ;

Eilers, M ;

Wedlich, D .

MECHANISMS OF DEVELOPMENT, 2005, 122 (04) :545-556

[10]

Feng Y, 2003, CANCER RES, V63, P8726

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