Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis

被引：8

作者：

Figarella-Branger, Dominique ^{[1
,2
]}

Mokhtari, Karima ^{[3
,4
,5
]}

Colin, Carole ^{[2
]}

Uro-Coste, Emmanuelle ^{[6
,7
]}

Jouvet, Anne ^{[8
]}

Dehais, Caroline ^{[9
]}

Carpentier, Catherine ^{[4
,5
]}

Villa, Chiara ^{[3
,10
]}

Maurage, Claude-Alain ^{[11
]}

Eimer, Sandrine ^{[12
,13
]}

Polivka, Marc ^{[14
]}

Vignaud, Jean-Michel ^{[15
]}

Laquerriere, Annie ^{[16
]}

Sevestre, Henri ^{[17
]}

Lechapt-Zalcman, Emmanuelle ^{[18
,19
]}

Quintin-Roue, Isabelle ^{[20
]}

Aubriot-Lorton, Marie-Helene ^{[21
]}

Diebold, Marie-Daniele ^{[22
]}

Viennet, Gabriel ^{[23
]}

Adam, Clovis ^{[24
]}

Loussouarn, Delphine ^{[25
]}

Michalak, Sophie ^{[26
]}

Rigau, Valerie ^{[27
]}

Heitzmann, Anne ^{[28
]}

Vandenbos, Fanny ^{[29
]}

Forest, Fabien ^{[30
]}

Chiforeanu, Danchristian ^{[31
]}

Tortel, Marie-Claire ^{[32
]}

Labrousse, Francois ^{[33
]}

Chenard, Marie-Pierre ^{[34
]}

Anh Tuan Nguyen ^{[35
]}

Varlet, Pascale ^{[36
]}

Kemeny, Jean Louis ^{[37
]}

Levillain, Pierre-Marie ^{[38
]}

Cazals-Hatem, Dominique ^{[39
]}

Richard, Pomone ^{[40
]}

Delattre, Jean-Yves ^{[4
,5
,9
]}

机构：

[1] Hop Enfants La Timone, APHM, Serv Anat Pathol & Neuropathol, Marseille, France

[2] Aix Marseille Univ, CRO2 UMR S 911, INSERM, F-13385 Marseille 05, France

[3] Grp Hosp Pitie Salpetriere, AP HP, Dept Neuropathol Raymond Escourolle, F-75634 Paris, France

[4] Univ Paris 06, Ctr Rech, Inst Cerveau & Moelle Epiniere, UMR 7225, Paris, France

[5] INSERM, U1127, Paris, France

[6] CHU Toulouse, Hop Rangueil, Serv Anat Pathol & Histologie Cytol, Toulouse, France

[7] Univ Toulouse, Ctr Rech Cancerol Toulouse, INSERM, U1037, Toulouse, France

[8] Hosp Civils Lyon, Ctr Pathol & Neuropathol Est, Bron, France

[9] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin 2, F-75634 Paris, France

[10] Hop Foch, Serv Anat Pathol, Suresnes, France

[11] CHU Lille, Pole Pathol Biol, Serv Anat Pathol, F-59037 Lille, France

[12] CHU Bordeaux, Hop Pellegrin, Serv Pathol Neuropathol, Bordeaux, France

[13] Univ Bordeaux Segalen, Histol & Pathol Mol Tumeurs, EA2406, Bordeaux, France

[14] Hop Lariboisiere, AP HP, Serv Anat & Cytol Pathol, F-75475 Paris, France

[15] CHU Nancy, Hop Cent, Anat Pathol Lab, Nancy, France

[16] CHU Rouen, Hop Charles Nicolle, Pathol Lab, Rouen, France

[17] CHU Amiens, Serv Anat & Cytol Pathol, Amiens, France

[18] CHU Caen, Hop Cote Nacre, Serv Anat Pathol, F-14000 Caen, France

[19] CNRS, UMR ISTCT 6301, CERVOxy, GIP CYCERON, Caen, France

[20] CHU Brest, Hop Cavale Blanche, Serv Anat Pathol, F-29285 Brest, France

[21] CHU Dijon, Plateau Tech Biol G Mack, Serv Anat & Cytol Pathol, Dijon, France

[22] CHU Reims, Hop Robert Debre, Lab Anat & Cytol Pathol, Reims, France

[23] CHU Besancon, Hop Jean Minjoz, Serv Anat & Cytol Pathol, F-25030 Besancon, France

[24] Hop Bicetre, AP HP, Serv Anat & Cytol Pathol, Le Kremlin Bicetre, France

[25] CHU Nantes, Hop Laennec, Serv Anat Pathol B, F-44035 Nantes 01, France

[26] CHU Angers, Dept Pathol Cellulaire & Tissulaire, Angers, France

[27] CHU Montpellier, Hop Gui de Chaulliac, Lab Anat & Cytol Pathol, Montpellier, France

[28] CHR Orleans, Hop Source, Serv Anat Pathol, Orleans, France

[29] CHU Nice, Hop Louis Pasteur, Lab Anat & Cytol Pathol, F-06202 Nice, France

[30] CHU St Etienne, Hop Nord, Serv Anat & Cytol Pathol, St Etienne, France

[31] CHU Rennes, Hop Pontchaillou, Serv Anat & Cytol Pathol, Renens, France

[32] Hop Civils Colmar, Serv Anat Pathol, Colmar, France

[33] CHU Limoges, Hop Dupuytren, Serv Anat Pathol, Limoges, France

[34] CHU Strasbourg, Hop Hautepierre, Serv Anat Pathol, F-67000 Strasbourg, France

[35] HIA St Anne, Serv Anat Pathol, Toulon, France

[36] CH St Anne, Dept Neuropathol, Paris, France

[37] CHU Clermont Ferrand, Hop Gabriel Montpied, Serv Anat & Cytol Pathol, Clermont Ferrand, France

[38] CHU Poitiers, Hop Mil, Lab Anat & Cytol Pathol, Poitiers, France

[39] Hop Beaujon, AP HP, Serv Anat & Cytol Pathol, Clichy, France

[40] Lab Anat & Cytol Pathol Feuillants, Toulouse, France

来源：

BRAIN PATHOLOGY | 2015年 / 25卷 / 04期

关键词：

1p/19q co-deletion; adult high-grade gliomas; GBMO; IDH1 R132H immunoexpression; necrosis; ANAPLASTIC OLIGODENDROGLIOMAS; GENETIC ALTERATIONS; IDH2; MUTATIONS; GLIOBLASTOMA; COMPONENT; TEMOZOLOMIDE; SURVIVAL; TRIAL;

D O I：

10.1111/bpa.12227

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diffuse adult high-grade gliomas (HGGs) with necrosis encompass anaplastic oligodendrogliomas (AOs) with necrosis (grade III), glioblastomas (GBM, grade IV) and glioblastomas with an oligodendroglial component (GBMO, grade IV). Here, we aimed to search for prognostic relevance of histological classification and molecular alterations of these tumors. About 210 patients were included (63 AO, 56 GBM and 91 GBMO). GBMO group was split into anaplastic oligoastrocytoma (AOA) with necrosis grade IV/GBMO, restricted to tumors showing intermingled astrocytic and oligodendroglial component, and GBM/GBMO based on tumors presenting oligodendroglial foci and features of GBM. Genomic arrays, IDH1 R132H expression analyses and IDH direct sequencing were performed. 1p/19q co-deletion characterized AO, whereas no IDH1 R132H expression and intact 1p/19q characterized both GBM and GBM/GBMO. AOA with necrosis/GBMO mainly demonstrated IDH1 R132H expression and intact 1p/19q. Other IDH1 or IDH2 mutations were extremely rare. Both histological and molecular classifications were predictive of progression free survival (PFS) and overall survival (OS) (P<10(-4)). Diffuse adult HGGs with necrosis can be split into three histomolecular groups of prognostic relevance: 1p/19q co-deleted AO, IDH1 R132H-GBM and 1p/19q intact IDH1 R132H+ gliomas that might be classified as IDH1 R132H+ GBM. Because of histomolecular heterogeneity, we suggest to remove the name GBMO.

引用

页码：418 / 428

页数：11

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