Caenorhabditis elegans: A Convenient In Vivo Model for Assessing the Impact of Food Bioactive Compounds on Obesity, Aging, and Alzheimer's Disease

被引：129

作者：

Shen, Peiyi ^{[1
]}

Yue, Yiren ^{[1
]}

Zheng, Jolene ^{[2
]}

Park, Yeonhwa ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

[2] CPCRL Inc, Prairieville, LA 70769 USA

来源：

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 9 | 2018年 / 9卷

基金：

美国食品与农业研究所;

关键词：

C; elegans; obesity; aging; Alzheimer's disease; BETA-AMYLOID PEPTIDE; MICROTUBULE-ASSOCIATED PROTEIN; LIFE-SPAN EXTENSION; C-ELEGANS; DIETARY RESTRICTION; OXIDATIVE STRESS; FAT STORAGE; (A-BETA(1-42))-INDUCED PARALYSIS; TAU; LONGEVITY;

D O I：

10.1146/annurev-food-030117-012709

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Caenorhabditis elegans is a small free-living nematode that lives in temperate soil environments. It has been widely employed as an animal model in research involving obesity, aging, and neurodegenerative diseases, including Alzheimer's disease, because of its various advantages, such as small size, large number of progeny, completely sequenced genome, and short life span, over traditional animal models of vertebrates. These benefits contribute to an ideal research model organism. In this review, we provide an introduction to C. elegans and its applications in obesity, aging, and Alzheimer's disease studies, with the aim of stimulating scientists to use C. elegans as an experimental model in various fields of research.

引用

页码：1 / 22

页数：22

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