A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses

被引：103

作者：

Tetens, J. ^{[1
]}

Widmann, P. ^{[2
]}

Kuehn, C. ^{[2
]}

Thaller, G. ^{[1
]}

机构：

[1] Univ Kiel, Inst Anim Breeding & Husb, D-24118 Kiel, Germany

[2] Leibniz Inst Farm Anim Biol, Res Unit Mol Biol, D-18196 Dummerstorf, Germany

来源：

ANIMAL GENETICS | 2013年 / 44卷 / 04期

关键词：

GWAS; QTL; horse; withers height; growth; SIZE; SEQUENCE; GENETICS; COMPLEX; TRAITS; GROWTH;

D O I：

10.1111/age.12031

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

A genome-wide association scan for loci affecting withers height was conducted in 782 German Warmblood stallions, which were genotyped using the Illumina EquineSNP50 Bead Chip. A principal components approach was applied to correct for population structure. The analysis revealed a single major QTL on ECA3 explaining similar to 18 per cent of the phenotypic variance, which is in concordance with recent reports from other horse populations. The LCORL/NCAPG locus represents a strong candidate gene for this QTL. This locus is among a small number that have consistently been identified to influence human height in several large meta-analyses. Furthermore, a mutation within the NCAPG gene was found to affect growth and body frame size in cattle. Together with the results of this study in German Warmbloods, these findings strongly indicate LCORL/NCAPG as a candidate locus for withers height in horses. Further studies are, however, needed to confirm this.

引用

页码：467 / 471

页数：5

共 22 条

[11] Polymorphic Regions Affecting Human Height Also Control Stature in Cattle
Pryce, Jennie E.
Hayes, Ben J.
Bolormaa, Sunduimijid
Goddard, Michael E.
[J]. GENETICS, 2011, 187 (03) : 981 - 984
[12] The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle
Setoguchi, K.
Watanabe, T.
Weikard, R.
Albrecht, E.
Kuehn, C.
Kinoshita, A.
Sugimoto, Y.
Takasuga, A.
[J]. ANIMAL GENETICS, 2011, 42 (06) : 650 - 655
[13] Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate
Setoguchi, Kouji
Furuta, Masako
Hirano, Takashi
Nagao, Tomoko
Watanabe, Toshio
Sugimoto, Yoshikazu
Takasuga, Akiko
[J]. BMC GENETICS, 2009, 10
[14] A Genome-Wide Association Study Reveals Loci Influencing Height and Other Conformation Traits in Horses
Signer-Hasler, Heidi
Flury, Christine
Haase, Bianca
Burger, Dominik
Simianer, Henner
Leeb, Tosso
Rieder, Stefan
[J]. PLOS ONE, 2012, 7 (05):
[15] Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size
Soranzo, Nicole
Rivadeneira, Fernando
Chinappen-Horsley, Usha
Malkina, Ida
Richards, J. Brent
Hammond, Naomi
Stolk, Lisette
Nica, Alexandra
Inouye, Michael
Hofman, Albert
Stephens, Jonathan
Wheeler, Eleanor
Arp, Pascal
Gwilliam, Rhian
Jhamai, P. Mila
Potter, Simon
Chaney, Amy
Ghori, Mohammed J. R.
Ravindrarajah, Radhi
Ermakov, Sergey
Estrada, Karol
Pols, Huibert A. P.
Williams, Frances M.
McArdle, Wendy L.
van Meurs, Joyce B.
Loos, Ruth J. F.
Dermitzakis, Emmanouil T.
Ahmadi, Kourosh R.
Hart, Deborah J.
Ouwehand, Willem H.
Wareham, Nicholas J.
Barroso, Ines
Sandhu, Manjinder S.
Strachan, David P.
Livshits, Gregory
Spector, Timothy D.
Uitterlinden, Andre G.
Deloukas, Panos
[J]. PLOS GENETICS, 2009, 5 (04)
[16] A single IGF1 allele is a major determinant of small size in dogs
Sutter, Nathan B.
Bustamante, Carlos D.
Chase, Kevin
Gray, Melissa M.
Zhao, Keyan
Zhu, Lan
Padhukasahasram, Badri
Karlins, Eric
Davis, Sean
Jones, Paul G.
Quignon, Pascale
Johnson, Gary S.
Parker, Heidi G.
Fretwell, Neale
Mosher, Dana S.
Lawler, Dennis F.
Satyaraj, Ebenezer
Nordborg, Magnus
Lark, K. Gordon
Wayne, Robert K.
Ostrander, Elaine A.
[J]. SCIENCE, 2007, 316 (5821) : 112 - 115
[17] From Galton to GWAS: quantitative genetics of human height
Visscher, Peter M.
McEvoy, Brian
Yang, Jian
[J]. GENETICS RESEARCH, 2010, 92 (5-6) : 371 - 379
[18] Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse
Wade, C. M.
Giulotto, E.
Sigurdsson, S.
Zoli, M.
Gnerre, S.
Imsland, F.
Lear, T. L.
Adelson, D. L.
Bailey, E.
Bellone, R. R.
Bloecker, H.
Distl, O.
Edgar, R. C.
Garber, M.
Leeb, T.
Mauceli, E.
MacLeod, J. N.
Penedo, M. C. T.
Raison, J. M.
Sharpe, T.
Vogel, J.
Andersson, L.
Antczak, D. F.
Biagi, T.
Binns, M. M.
Chowdhary, B. P.
Coleman, S. J.
Della Valle, G.
Fryc, S.
Guerin, G.
Hasegawa, T.
Hill, E. W.
Jurka, J.
Kiialainen, A.
Lindgren, G.
Liu, J.
Magnani, E.
Mickelson, J. R.
Murray, J.
Nergadze, S. G.
Onofrio, R.
Pedroni, S.
Piras, M. F.
Raudsepp, T.
Rocchi, M.
Roed, K. H.
Ryder, O. A.
Searle, S.
Skow, L.
Swinburne, J. E.
[J]. SCIENCE, 2009, 326 (5954) : 865 - 867
[19] Genome-wide association analysis identifies 20 loci that influence adult height
Weedon, Michael N.
Lango, Hana
Lindgren, Cecilia M.
Wallace, Chris
Evans, David M.
Mangino, Massimo
Freathy, Rachel M.
Perry, John R. B.
Stevens, Suzanne
Hall, Alistair S.
Samani, Nilesh J.
Shields, Beverly
Prokopenko, Inga
Farrall, Martin
Dominiczak, Anna
Johnson, Toby
Bergmann, Sven
Beckmann, Jacques S.
Vollenweider, Peter
Waterworth, Dawn M.
Mooser, Vincent
Palmer, Colin N. A.
Morris, Andrew D.
Ouwehand, Willem H.
Caulfield, Mark
Munroe, Patricia B.
Hattersley, Andrew T.
McCarthy, Mark I.
Frayling, Timothy M.
[J]. NATURE GENETICS, 2008, 40 (05) : 575 - 583
[20] Metabolomic profiles indicate distinct physiological pathways affected by two loci with major divergent effect on Bos taurus growth and lipid deposition
Weikard, Rosemarie
Altmaier, Elisabeth
Suhre, Karsten
Weinberger, Klaus M.
Hammon, Harald M.
Albrecht, Elke
Setoguchi, Kouji
Takasuga, Akiko
Kuehn, Christa
[J]. PHYSIOLOGICAL GENOMICS, 2010, 42A (02) : 79 - 88

← 1 2 3 →