A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses

被引：105

作者：

Tetens, J. ^{[1
]}

Widmann, P. ^{[2
]}

Kuehn, C. ^{[2
]}

Thaller, G. ^{[1
]}

机构：

[1] Univ Kiel, Inst Anim Breeding & Husb, D-24118 Kiel, Germany

[2] Leibniz Inst Farm Anim Biol, Res Unit Mol Biol, D-18196 Dummerstorf, Germany

来源：

ANIMAL GENETICS | 2013年 / 44卷 / 04期

关键词：

GWAS; QTL; horse; withers height; growth; SIZE; SEQUENCE; GENETICS; COMPLEX; TRAITS; GROWTH;

D O I：

10.1111/age.12031

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

A genome-wide association scan for loci affecting withers height was conducted in 782 German Warmblood stallions, which were genotyped using the Illumina EquineSNP50 Bead Chip. A principal components approach was applied to correct for population structure. The analysis revealed a single major QTL on ECA3 explaining similar to 18 per cent of the phenotypic variance, which is in concordance with recent reports from other horse populations. The LCORL/NCAPG locus represents a strong candidate gene for this QTL. This locus is among a small number that have consistently been identified to influence human height in several large meta-analyses. Furthermore, a mutation within the NCAPG gene was found to affect growth and body frame size in cattle. Together with the results of this study in German Warmbloods, these findings strongly indicate LCORL/NCAPG as a candidate locus for withers height in horses. Further studies are, however, needed to confirm this.

引用

页码：467 / 471

页数：5

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