In vitro and in vivo antioxidant properties of Vaccinium myrtillus

被引：10

作者：

Martín-Aragón, S ^{[1
]}

Basabe, B ^{[1
]}

Benedí, JM ^{[1
]}

Villar, AM ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Pharm, Dept Pharmacol, Madrid, Spain

来源：

PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 02期

关键词：

anthocyanoside; lipid peroxidation; liver; superoxide anion; Vaccinium myrtillus;

D O I：

10.1076/phbi.37.2.109.6091

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In vitro and in vivo antioxidant properties of an anthocyanoside complex extract from Vaccinium myrtillus (AVM) were evaluated. This extract scavenged superoxide anion in the hypoxanthine-xanthine oxidase system and inhibited CCl4-NADPH-stimulated lipid peroxidation irt microsomes. It was found that pretreatment of mice with 250 and 500 mg/kg oral dosages, respectively: of AVM inhibited significantly liver lipid peroxidation stimulated by FeCl2-ascorbic acid-ADP mixture. These results suggest that AVM might be useful as a liver protective agent and in the prevention of other diseases caused by oxidative stress.

引用

页码：109 / 113

页数：5

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