congestive heart failure;
bone formation;
bone resorption;
heart transplantation;
D O I:
10.1016/j.cca.2005.10.006
中图分类号:
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号:
1001 ;
摘要:
Congestive heart failure (CHF) is a chronic disease, whose incidence is especially growing in the subpopulation of elderly people. CHF is characterized by dyspnea and fatigue at rest or with exertion, ankle swelling and pulmonary edema. Cardiac transplantation is the ultimate therapeutic measure in patients with end-stage CHF. Some risk factors associated with CHF such as low mobility renal failure, and prescription of specific drugs may predispose patients to develop osteoporosis. This review article gives an overview about markers of bone metabolism in CHF patients as well as in heart transplant recipients. At first, the physiology of bone metabolism is summarized. Then, a short description of different bone formation and resorption markers is presented. They can be used to characterize actual bone metabolism and can be helpful to explain possible mechanisms of bone loss. Regarding pre-transplant CHF patients, available data indicate that the disturbances in bone metabolism are only Subtle. Heart transplant recipients, however, are at increased risk for osteoporotic bone loss due to the use of immunosuppressive agents such as corticosteroids and calcineurin inhibitors. Preventive strategies are able to normalize bone metabolism and to attenuate the high bone loss during the first year after heart transplantation. (c) 2005 Elsevier B.V. All rights reserved.
机构:
Sechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia
Topolyanskaya, S.
Osipovskaya, I.
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机构:
War Vet Hosp N3, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia
Osipovskaya, I.
Lifanova, L.
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机构:
Sechenov Univ, First Moscow StateMed Univ, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia
Lifanova, L.
Eliseeva, T.
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机构:
War Vet Hosp N3, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia
Eliseeva, T.
Vakulenko, O.
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h-index: 0
机构:
War Vet Hosp N3, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia
Vakulenko, O.
Dvoretsky, L.
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h-index: 0
机构:
Sechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, RussiaSechenov Univ, First Moscow State Med Univ, Dept Hosp therapy N2, Moscow, Russia