RNA interference-based therapy and its delivery systems

被引：242

作者：

Chen, Xiuhui ^{[1
,2
]}

Mangala, Lingegowda S. ^{[1
,3
]}

Rodriguez-Aguayo, Cristian ^{[3
,4
]}

Kong, Xianchao ^{[2
]}

Lopez-Berestein, Gabriel ^{[3
,4
]}

Sood, Anil K. ^{[1
,3
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Harbin, Heilongjiang, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNAs, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CANCER AND METASTASIS REVIEWS | 2018年 / 37卷 / 01期

基金：

美国国家卫生研究院;

关键词：

RNA interference; Delivery systems; Nanoparticles; Cancer therapy; MESENCHYMAL STEM-CELLS; NANOSTRUCTURED LIPID CARRIERS; POLYMER HYBRID NANOPARTICLES; VASCULAR ENDOTHELIAL-CELLS; BLOOD-BRAIN-BARRIER; HEPATITIS-B-VIRUS; SIRNA DELIVERY; TARGETED DELIVERY; MULTIDRUG-RESISTANCE; BREAST-CANCER;

D O I：

10.1007/s10555-017-9717-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery. Effective delivery systems are essential to enable the full therapeutic potential of RNAi. An ideal nanocarrier not only addresses the challenges of delivering naked siRNA/miRNA, including its chemically unstable features, extracellular and intracellular barriers, and innate immune stimulation, but also offers "smart" targeted delivery. Over the past decade, great efforts have been undertaken to develop RNAi delivery systems that overcome these obstacles. This review presents an update on current progress in the therapeutic application of RNAi with a focus on cancer therapy and strategies for optimizing delivery systems, such as lipid-based nanoparticles.

引用

页码：107 / 124

页数：18

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