Metal Ion Complexes with Pyrazoles, Aziridines and Diaziridines - Synthesis and Biological Activity

被引：14

作者：

Malinowska, Katarzyna ^{[1
]}

Lorenz, Ingo-Peter ^{[2
]}

Sadowska, Beata ^{[3
]}

Mucha, Paulina ^{[4
]}

机构：

[1] Med Univ Lodz, Dept Allergol & Resp Rehabil, Chair Otolaryngol 2, Lodz, Poland

[2] Ludwig Maximilians Univ Munchen, Dept Chem, Munich, Germany

[3] Univ Lodz, Dept Immunol & Infect Biol, Fac Biol & Environm Protect, Lodz, Poland

[4] Med Univ Lodz, Dept Cosmet Raw Mat Chem, Fac Pharm, POB 90-151,Muszynskiego 1, Lodz, Poland

来源：

CURRENT MEDICINAL CHEMISTRY | 2019年 / 26卷 / 04期

关键词：

Synthesis ligand; complexes; metal ions; pyrazole; aziridine; diaziridine; antioxidant; antimicrobial; COPPER(II) COMPLEXES; NITROGEN INVERSION; CYTOTOXIC ACTIVITY; PD(II) COMPLEXES; DERIVATIVES; STEREODYNAMICS; ZINC(II); CADMIUM; NICKEL;

D O I：

10.2174/0929867325666180221124447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterocyclic compounds containing nitrogen ions, like pyrazoles, aziridines, diaziridines and their metal ion complexes with Cu(II), Zn(II) and Ru(IlI) and others exhibit a wide range of biological activity, including mainly anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. Biological significance of these molecules and thus their potential use in medicine has driven growing interest into their coordination chemistry. A knowledge of the relationship between the structure of chemical compounds and their activity is needed for the synthesis of the preparations possessing the most beneficial features. The choice of interposed substituents may improve biocidal and antitumor action, reduce the toxicity of the initial substance, or even completely eliminate its adverse effects for healthy tissues. The main aim of this review paper is to present the current state of knowledge concerning the synthesis and biological activity of complexes with small heterocyclic ligands containing transition metal ions.

引用

页码：648 / 663

页数：16

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