From funny current to HCN channels: 20 years of excitation

被引：169
作者：
Accili, EA [1 ]
Proenza, C
Baruscotti, M
DiFrancesco, D
机构：
[1] Unita Univ Milan, Dipartimento Fisiol & Biochim Gen, Lab Fisiol Mol & Neurobiol, I-20133 Milan, Italy
[2] Unita Univ Milan, Ist Nazl Fis Mat, I-20133 Milan, Italy
[3] Simon Fraser Univ, Sch Kinesiol, Burnaby, BC V5A 1S6, Canada
来源：
NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷
关键词：
D O I：
10.1152/physiologyonline.2002.17.1.32
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K+ and Na+, modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
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页码：32 / 37
页数：6
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