Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells

被引：6
作者：
Gianella, Sara [1 ]
Mehta, Sanjay R. [1 ]
Young, Jason A. [1 ]
Vargas, Milenka V. [1 ]
Little, Susan J. [1 ]
Richman, Douglas D. [1 ,2 ]
Pond, Sergei L. Kosakovsky [1 ]
Smith, Davey M. [1 ,2 ]
机构：
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
[2] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
来源：
VIROLOGY | 2012年 / 434卷 / 01期
基金：
瑞士国家科学基金会; 美国国家卫生研究院;
关键词：
HIV transmission; Seminal cells; X4 tropic virus; Compartmentalization; TROPISM; RESISTANCE; INFERENCE; SUBTYPE;
D O I：
10.1016/j.virol.2012.09.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：2 / 4
页数：3
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