Broken hearts: Iron overload, ferroptosis and cardiomyopathy

被引:65
作者
Conrad, Marcus [1 ]
Proneth, Bettina [1 ]
机构
[1] Helmholtz Zentrum Munchen, Inst Dev Genet, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany
关键词
CELL-DEATH;
D O I
10.1038/s41422-019-0150-y
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In a recently published paper in Proc Natl Acad Sci USA, Fang et al. elegantly demonstrated that doxorubicin treatment or transient ischemia/reperfusion in mice triggers ferroptosis, a distinctive form of necrotic cell death marked by irondependent lipid peroxidation, which is the main underlying mechanism in the pathogenesis of cardiomyopathy.
引用
收藏
页码:263 / 264
页数:2
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