Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells

被引:4
作者
Fujiwara, Yasuyuki [1 ]
Yamamoto, Chika [2 ]
Inagaki, Takayuki [2 ]
Satoh, Masahiko [1 ]
Kaji, Toshiyuki [3 ]
机构
[1] Aichi Gakuin Univ, Sch Pharm, Lab Pharmaceut Hlth Sci, Chikusa Ku, Nagoya, Aichi 4648650, Japan
[2] Hokuriku Univ, Fac Pharmaceut Sci, Dept Environm Hlth, Kanazawa, Ishikawa 9201181, Japan
[3] Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Environm Hlth, Noda, Chiba 2788510, Japan
基金
日本学术振兴会;
关键词
Arsenite; Bismuth; Proteoglycan; Vascular endothelial cell; Atherosclerosis; CADMIUM TOXICITY; SMOOTH-MUSCLE; METALLOTHIONEIN; BIOLOGY; TISSUE; ATHEROSCLEROSIS; ATHEROGENESIS; CYTOTOXICITY; MODULATION; EXPRESSION;
D O I
10.2131/jts.37.837
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Chronic ingestion of arsenic is associated with an increased risk of vascular disease such as atherosclerosis. Previously, we showed that arsenite inhibits the synthesis of general proteoglycans (PGs), which are key molecules in the progression of atherosclerosis, in vascular endothelial cells. In the present study, we investigated the effect of several metals on arsenite-induced inhibitory effect in endothelial cells. The results indicate that, after 24-hr incubation, the inhibition of PG synthesis caused by sodium arsenite was protected by bismuth nitrate but not zinc sulfate, manganese chloride, nickel chloride or cobalt chloride. The accumulation of arsenic in the cell layer was significantly decreased by bismuth after 12-hr incubation and that of bismuth was also decreased by arsenite. It was therefore suggested that the protective effect of bismuth against the inhibitory effect of arsenite on PG synthesis in vascular endothelial cells may be due, at least in part, to the decrease in cellular arsenic accumulation.
引用
收藏
页码:837 / 843
页数:7
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