Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins

被引：99

作者：

Wilkinson, Brendan L. ^{[1
]}

Stone, Robin S. ^{[1
]}

Capicciotti, Chantelle J. ^{[2
]}

Thaysen-Andersen, Morten ^{[3
]}

Matthews, Jacqueline M. ^{[4
]}

Packer, Nicolle H. ^{[3
]}

Ben, Robert N. ^{[2
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

[3] Macquarie Univ, Biomol Frontiers Res Ctr, N Ryde, NSW 2109, Australia

[4] Univ Sydney, Sch Mol Biosci, Sydney, NSW 2006, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 15期

基金：

澳大利亚研究理事会;

关键词：

antifreeze proteins; chemical ligation; glycopeptides; glycoproteins; thermal hysteresis; NATIVE CHEMICAL LIGATION; FREEZING RESISTANCE; ANTARCTIC FISHES; POLAR FISH; CONFORMATION; ADSORPTION; ICE; PEPTIDES; PROTEINS; DESULFURIZATION;

D O I：

10.1002/anie.201108682

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Don't freeze! A native chemical ligation-desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3606 / 3610

页数：5

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