The Spatial Organization of the Human Genome

被引：274

作者：

Bickmore, Wendy A. ^{[1
]}

机构：

[1] Univ Edinburgh, MRC Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14 | 2013年 / 14卷

基金：

英国医学研究理事会;

关键词：

chromatin; chromosome territory; enhancer; nuclear periphery; nucleus; CHROMOSOME CONFORMATION CAPTURE; ORDER CHROMATIN ARRANGEMENTS; GENE-EXPRESSION; NUCLEAR REORGANIZATION; CELL-TYPE; DE-NOVO; DOMAINS; REPLICATION; TRANSCRIPTION; REVEALS;

D O I：

10.1146/annurev-genom-091212-153515

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In vivo, the human genome functions as a complex, folded, three-dimensional chromatin polymer. Understanding how the human genome is spatially organized and folded inside the cell nucleus is therefore central to understanding how genes are regulated in normal development and dysregulated in disease. Established light microscopy-based approaches and more recent molecular chromosome conformation capture methods are now combining to give us unprecedented insight into this fascinating aspect of human genomics.

引用

页码：67 / 84

页数：18

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