Plasmodium falciparum: Organelle-specific acquisition of lipoic acid

被引：26

作者：

Gunther, Svenja

Storm, Janet

Muller, Sylke ^{[1
]}

机构：

[1] Univ Glasgow, Fac Biomed Life Sci, Glasgow Biomed Res Ctr, Div Infect & Immun, Glasgow G12 8TA, Lanark, Scotland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 04期

基金：

英国惠康基金;

关键词：

Malaria; Drug target; Apicoplast; Mitochondrion; Lipoylation; LIPOATE-PROTEIN LIGASE; DEHYDROGENASE COMPLEXES; LIPOYLATION PATHWAYS; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; METABOLIC MAPS; GENOME; CELL; EXPRESSION; APICOPLAST;

D O I：

10.1016/j.biocel.2008.10.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoic acid is an essential cofactor of multienzyme complexes that are integral to energy metabolism, amino acid degradation and folate metabolism. In recent years it has been shown that the malaria parasite Plasmodium falciparum possesses organelle-specific pathways that guarantee the lipoylation of their multienzyme complexes which occur in the mitochondrion (LA salvage) and in a plastid-like organelle, the apicoplast (LA biosynthesis). The unique distribution of the lipoylation machineries and the unique metabolic requirements of the parasites present a situation that is potentially exploitable for new ways to improve malaria control. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：748 / 752

页数：5

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