The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome

被引：487

作者：

Dietrich, FS

Voegeli, S

Brachat, S

Lerch, A

Gates, K

Steiner, S

Mohr, C

Pöhlmann, R

Luedi, P

Choi, SD

Wing, RA

Flavier, A

Gaffney, TD

Phillippsen, P

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[2] Duke Univ, Med Ctr, Dept Microbiol & Mol Genet, Durham, NC 27710 USA

[3] Syngenta Biotechnol Inc, Res Triangle Pk, NC 27709 USA

[4] Clemson Univ, Dept Agron, Clemson, SC 29634 USA

[5] Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA

来源：

SCIENCE | 2004年 / 304卷 / 5668期

关键词：

D O I：

10.1126/science.1095781

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

引用

页码：304 / 307

页数：4

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