Cytoplasmic access by intracellular bacterial pathogens

被引：49

作者：

Fredlund, Jennifer ^{[1
]}

Enninga, Jost ^{[1
]}

机构：

[1] Inst Pasteur, Unite Dynam Interact Hote Pathogene, F-75724 Paris, France

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 03期

基金：

欧洲研究理事会;

关键词：

intracellular bacteria; vacuolar rupture; membrane trafficking; host cell death; NONCANONICAL INFLAMMASOME ACTIVATION; ENTERICA SEROVAR TYPHIMURIUM; FORMATION-MEDIATED EGRESS; HOST-CELL MEMBRANES; LISTERIA-MONOCYTOGENES; LEGIONELLA-PNEUMOPHILA; MYCOBACTERIUM-TUBERCULOSIS; SHIGELLA-FLEXNERI; FRANCISELLA-TULARENSIS; PHAGOSOMAL ESCAPE;

D O I：

10.1016/j.tim.2014.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens rupture their endocytic vacuoles as well as the mechanisms used to accomplish this task by bacterial species for which host cytoplasmic localization has only recently been identified. We also discuss the consequences for pathogenesis resulting from this change in intracellular localization, with a particular focus on the role of the host. What emerges is that cytoplasmic access plays an important role in the pathophysiology of an increasing number of intracellular bacterial pathogens.

引用

页码：128 / 137

页数：10

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