Gadolinium-based contrast agents review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients

被引：49
|
作者：
Blumfield, Einat [1 ]
Swenson, David W. [2 ]
Iyer, Ramesh S. [3 ]
Stanescu, A. Luana [3 ]
机构：
[1] Childrens Hosp Montefiore, Albert Einstein Coll Med, Dept Radiol, 111E 210th St, Bronx, NY 10461 USA
[2] Brown Univ, Alpert Med Sch, Dept Diagnost Imaging, Rhode Isl Hosp,Hasbro Childrens Hosp, Providence, RI USA
[3] Univ Washington, Sch Med, Dept Radiol, Seattle Childrens Hosp, Seattle, WA 98195 USA
来源：
PEDIATRIC RADIOLOGY | 2019年 / 49卷 / 04期
关键词：
Brain; Children; Deposition; Gadolinium; Gadolinium-based contrast agents; Magnetic resonance imaging; T1; signal; UNENHANCED T1-WEIGHTED IMAGES; NEPHROGENIC SYSTEMIC FIBROSIS; HUMAN BONE TISSUE; DENTATE NUCLEUS; GLOBUS-PALLIDUS; MR-IMAGES; GADOBENATE DIMEGLUMINE; MULTIPLE ADMINISTRATIONS; PROGRESSIVE INCREASE; GD-DTPA;
D O I：
10.1007/s00247-018-4304-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Gadolinium has been used as a base for contrast agents in MRI for the last three decades. Numerous studies over the last 4years have reported increased signal intensity in deep brain nuclei in non-contrast MRI images following gadolinium-based contrast agent (GBCA) administration. Pathology studies performed on adults and children, and rodent necropsy studies have also shown gadolinium deposition in brain and other tissues after GBCA administration. The purpose of this review was to summarize and discuss the knowledge gained from these reports and the relevance for imaging pediatric patients.
引用
收藏
页码：448 / 457
页数：10
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