Gadolinium-based contrast agents review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients

被引：51

作者：

Blumfield, Einat ^{[1
]}

Swenson, David W. ^{[2
]}

Iyer, Ramesh S. ^{[3
]}

Stanescu, A. Luana ^{[3
]}

机构：

[1] Childrens Hosp Montefiore, Albert Einstein Coll Med, Dept Radiol, 111E 210th St, Bronx, NY 10461 USA

[2] Brown Univ, Alpert Med Sch, Dept Diagnost Imaging, Rhode Isl Hosp,Hasbro Childrens Hosp, Providence, RI USA

[3] Univ Washington, Sch Med, Dept Radiol, Seattle Childrens Hosp, Seattle, WA 98195 USA

来源：

PEDIATRIC RADIOLOGY | 2019年 / 49卷 / 04期

关键词：

Brain; Children; Deposition; Gadolinium; Gadolinium-based contrast agents; Magnetic resonance imaging; T1; signal; UNENHANCED T1-WEIGHTED IMAGES; NEPHROGENIC SYSTEMIC FIBROSIS; HUMAN BONE TISSUE; DENTATE NUCLEUS; GLOBUS-PALLIDUS; MR-IMAGES; GADOBENATE DIMEGLUMINE; MULTIPLE ADMINISTRATIONS; PROGRESSIVE INCREASE; GD-DTPA;

D O I：

10.1007/s00247-018-4304-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Gadolinium has been used as a base for contrast agents in MRI for the last three decades. Numerous studies over the last 4years have reported increased signal intensity in deep brain nuclei in non-contrast MRI images following gadolinium-based contrast agent (GBCA) administration. Pathology studies performed on adults and children, and rodent necropsy studies have also shown gadolinium deposition in brain and other tissues after GBCA administration. The purpose of this review was to summarize and discuss the knowledge gained from these reports and the relevance for imaging pediatric patients.

引用

页码：448 / 457

页数：10

共 76 条

[1]

[Anonymous], 2017, RSNA DAIL B

[2] Gadolinium deposition in the brain: association with various GBCAs using a generalized additive model [J].

Bae, Sohi ;

Lee, Ho-Joon ;

Han, Kyunghwa ;

Park, Yae-Won ;

Choi, Yoon Seong ;

Ahn, Sung Soo ;

Kim, Jinna ;

Lee, Seung-Koo .

EUROPEAN RADIOLOGY, 2017, 27 (08) :3353-3361

[3] Safety and efficacy of gadoteric acid in pediatric magnetic resonance imaging: overview of clinical trials and post-marketing studies [J].

Balassy, Csilla ;

Roberts, Donna ;

Miller, Stephen F. .

PEDIATRIC RADIOLOGY, 2015, 45 (12) :1831-1841

[4] PHASE-III MULTICENTER CLINICAL INVESTIGATION TO DETERMINE THE SAFETY AND EFFICACY OF GADOTERIDOL IN CHILDREN SUSPECTED OF HAVING NEUROLOGIC DISEASE [J].

BALL, WS ;

NADEL, SN ;

ZIMMERMAN, RA ;

BYRD, SE ;

DIETRICH, RB ;

PRENGER, EC ;

DRAYER, BP ;

NELSON, MD ;

MORGAN, FW ;

ALTMAN, NR ;

CURRAN, JG ;

CARVLIN, MJ ;

MORRIS, MR .

RADIOLOGY, 1993, 186 (03) :769-774

[5] Signal Enhancement of the Dentate Nucleus at Unenhanced MR Imaging after Very High Cumulative Doses of the Macrocyclic Gadolinium-based Contrast Agent Gadobutrol: An Observational Study [J].

Bjornerud, Atle ;

Vatnehol, Svein Are Sirirud ;

Larsson, Christopher ;

Due-Tonnessen, Paulina ;

Hol, Per Kristian ;

Groote, Inge Rasmus .

RADIOLOGY, 2017, 285 (02) :434-444

[6] Survey of gadolinium-based contrast agent utilization among the members of the Society for Pediatric Radiology: a Quality and Safety Committee report [J].

Blumfield, Einat ;

Moore, Michael M. ;

Drake, Mary K. ;

Goodman, Thomas R. ;

Lewis, Kristopher N. ;

Meyer, Laura T. ;

Ngo, Thang D. ;

Sammet, Christina ;

Stanescu, Arta Luana ;

Swenson, David W. ;

Slovis, Thomas L. ;

Iyer, Ramesh S. .

PEDIATRIC RADIOLOGY, 2017, 47 (06) :665-673

[7] Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats [J].

Bussi, Simona ;

Coppo, Alessandra ;

Botteron, Catherine ;

Fraimbault, Valerie ;

Fanizzi, Antonello ;

De Laurentiis, Elisa ;

Colombo Serra, Sonia ;

Kirchin, Miles A. ;

Tedoldi, Fabio ;

Maisano, Federico .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2018, 47 (03) :746-752

[8] Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol [J].

Cao, Yan ;

Huang, Daisy Q. ;

Shih, George ;

Prince, Martin R. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2016, 206 (02) :414-419

[9] Quantification of gadolinium in fresh skin and serum samples from patients with nephrogenic systemic fibrosis [J].

Christensen, Kevin N. ;

Lee, Christine U. ;

Hanley, Matthew M. ;

Leung, Nelson ;

Moyer, Thomas P. ;

Pittelkow, Mark R. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 64 (01) :91-96

[10] Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study [J].

Conte, Giorgio ;

Preda, Lorenzo ;

Cocorocchio, Emilia ;

Raimondi, Sara ;

Giannitto, Caterina ;

Minotti, Marta ;

De Piano, Francesca ;

Petralia, Giuseppe ;

Ferrucci, Pier Francesco ;

Bellomi, Massimo .

EUROPEAN RADIOLOGY, 2017, 27 (10) :4372-4378

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