Maternal obesity and Down syndrome in the offspring: is there a link?

被引：2
作者：
Ghidini, Alessandro [1 ]
机构：
[1] Inova Alexandria Hosp, Perinatal Diagnost Ctr, Alexandria, VA 22304 USA
来源：
PRENATAL DIAGNOSIS | 2014年 / 34卷 / 04期
关键词：
ABNORMAL FOLATE METABOLISM; NEURAL-TUBE DEFECTS; RISK-FACTORS; GENETIC SONOGRAPHY; WEIGHT; PREGNANCY; POLYMORPHISMS; FORTIFICATION; METAANALYSIS; OVERWEIGHT;
D O I：
10.1002/pd.4341
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
What's already known about this topic? Obesity has several adverse effects on the fetal and neonatal outcomes Obesity leads to underdetection of fetal sonographic markers of aneuploidies and of fetal anomalies, as well as underperformance of maternal serum screening test for common aneuploidies Obesity can be associated with malnutrition and lower levels of essential vitamins What does this study add? The reported increased risk of offspring with Down syndrome in obese women (corrected for maternal age) could be due to more frequent non-disjunctional events or under-detection of affected fetuses
引用
收藏
页码：307 / 309
页数：3
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