DDT/DDE and breast cancer: A meta-analysis

被引：44

作者：

Ingber, Susan Z. ^{[1
]}

Buser, Melanie C. ^{[1
]}

Pohl, Hana R. ^{[1
]}

Abadin, Henry G. ^{[1
]}

Murray, H. Edward ^{[1
]}

Scinicariello, Franco ^{[1
]}

机构：

[1] ATSDR, Div Toxicol & Human Hlth Sci, Atlanta, GA 30341 USA

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2013年 / 67卷 / 03期

关键词：

DDT; DDE; Breast cancer; Systematic review; Meta-analysis; PLASMA ORGANOCHLORINE LEVELS; ADIPOSE-TISSUE CONCENTRATIONS; NESTED CASE-CONTROL; POLYCHLORINATED-BIPHENYLS; SERUM ORGANOCHLORINES; AFRICAN-AMERICAN; PESTICIDE LEVELS; BLOOD-LEVELS; LONG-ISLAND; RISK;

D O I：

10.1016/j.yrtph.2013.08.021

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The biological basis for investigating dichlorodiphenyltrichloroethane (DDT) exposure and breast cancer risk stems from in vitro and animal studies indicating that DDT has estrogenic properties. The objective of this study was to update a meta-analysis from 2004 which found no association between dichlorodiphenyldichloroethylene (DDE) and breast cancer. We searched PubMed and Web of Science for studies published through June 2012 assessing DDT/DDE exposure and breast cancer. Summary Odds Ratios (ORs) with 95% confidence intervals (CIs) were calculated for the prevalence of breast cancer in the highest versus the lowest exposed groups for DDT and DDE. Difference of means of exposure for cases versus controls was analyzed for DDT and DDE. From the 500 studies screened, 46 were included in the meta-analysis. Slightly elevated, but not statistically significant summary ORs were found for DDE (1.05; 95% CI: 0.93-1.18) and DDT (1.02; 95% CI: 0.92-1.13). Lipid adjusted difference of means analysis found a significantly higher DDE concentration in cases versus controls (11.30 ng/g lipid; p = 0.01). No other difference of means analysis found significant relationships. The existing information does not support the hypothesis that exposure to DDT/DDE increases the risk of breast cancer in humans. Published by Elsevier Inc.

引用

页码：421 / 433

页数：13

共 68 条

[1] Residue levels of DDE and PCBs in the blood serum of women in the Port Said region of Egypt [J].

Ahmed, MT ;

Loutfy, N ;

El Shiekh, E .

JOURNAL OF HAZARDOUS MATERIALS, 2002, 89 (01) :41-48

[2]

Aronson KJ, 2000, CANCER EPIDEM BIOMAR, V9, P55

[3]

*ATSDR, 2002, TOX PROF DDT DDE DDD

[4] Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines [J].

Aube, Michel ;

Larochelle, Christian ;

Ayotte, Pierre .

ENVIRONMENTAL RESEARCH, 2011, 111 (03) :337-347

[5] Organochlorine pesticide content of breast adipose tissue from women with breast cancer and control subjects [J].

Bagga, D ;

Anders, KH ;

Wang, HJ ;

Roberts, E ;

Glaspy, JA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (09) :750-753

[6] OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].

BEGG, CB ;

MAZUMDAR, M .

BIOMETRICS, 1994, 50 (04) :1088-1101

[7] Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies [J].

Beral, V. ;

Bull, D. ;

Pirie, K. ;

Reeves, G. ;

Peto, R. ;

Skegg, D. ;

LaVecchia, C. ;

Magnusson, C. ;

Pike, M. C. ;

Thomas, D. ;

Hamajima, N. ;

Hirose, K. ;

Tajima, K. ;

Rohan, T. ;

Friedenreich, C. M. ;

Calle, E. E. ;

Gapstur, S. M. ;

Patel, A. V. ;

Coates, R. J. ;

Liff, J. M. ;

Talamini, R. ;

Chantarakul, N. ;

Koetsawang, S. ;

Rachawat, D. ;

Marcou, Y. ;

Kakouri, E. ;

Duffy, S. W. ;

Morabia, A. ;

Schuman, L. ;

Stewart, W. ;

Szklo, M. ;

Coogan, P. F. ;

Palmer, J. R. ;

Rosenberg, L. ;

Band, P. ;

Coldman, A. J. ;

Gallagher, R. P. ;

Hislop, T. G. ;

Yang, P. ;

Cummings, S. R. ;

Canfell, K. ;

Sitas, F. ;

Chao, P. ;

Lissowska, J. ;

Horn-Ross, P. L. ;

John, E. M. ;

Kolonel, L. M. ;

Nomura, A. M. Y. ;

Ghiasvand, R. ;

Hu, J. .

LANCET ONCOLOGY, 2012, 13 (11) :1141-1151

[8] Complex organochlorine pesticide mixtures as determinant factor for breast cancer risk: a population-based case-control study in the Canary Islands (Spain) [J].

Boada, Luis D. ;

Zumbado, Manuel ;

Alberto Henriquez-Hernandez, Luis ;

Almeida-Gonzalez, Maira ;

Alvarez-Leon, Eva E. ;

Serra-Majem, Lluis ;

Luzardo, Octavio P. .

ENVIRONMENTAL HEALTH, 2012, 11

[9] Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area [J].

Bradman, Asa ;

Schwartz, Jackie M. ;

Fenster, Laura ;

Barr, Dana B. ;

Holland, Nina T. ;

Eskenazi, Brenda .

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2007, 17 (04) :388-399

[10] The link between the insecticide heptachlor epoxide, estradiol, and breast cancer [J].

Cassidy, RA ;

Natarajan, S ;

Vaughan, GM .

BREAST CANCER RESEARCH AND TREATMENT, 2005, 90 (01) :55-64

← 1 2 3 4 5 6 7 →