An efficient ionic liquid mediated synthesis of substituted 5H[1,3]-thiazolo[2,3-b]quinazoline-3,5-(2H)-dione and 5H-thiazolo[2,3-b]quinazolin-5-one

被引：8

作者：

Yadav, Ashok K. ^{[1
]}

Dhakad, Pankaj ^{[1
]}

Sharma, Gopi Ram ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 45期

关键词：

Quinazolinethiones; Thiazoloquinazolinone; Thiazoloquinazolindione; Ionic liquid; THIAZOLO 2,3-B QUINAZOLINE; DERIVATIVES;

D O I：

10.1016/j.tetlet.2013.08.090

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, environmentally benign two-step synthesis of 5H[1,3]-thiazolo[2,3-b]quinazoline-3,5-(2H)-dione and 5H-thiazolo[2,3-b]quinazolin-5-one derivatives has been accomplished stepwise. The substituted 2-aminobenzoic acid upon condensation with thiourea in 1-buty1-3-methylimidazolium bromide at moderate temperature under nitrogen atmosphere yielded 2-thioxo-1H-4-quinazolinones. The resulting intermediate 2-thioxo-1H-4-quinazolinones, when reacted with 2-chloroethanoic acid/2-chloropropanal underwent cyclization to yield the desired product in excellent yields. (C) 2013 Published by Elsevier Ltd.

引用

页码：6061 / 6063

页数：3

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