Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides

被引：83
作者：
Qin, Chong [1 ]
Feng, Peng [1 ]
Ou, Yang [1 ]
Shen, Tao [1 ]
Wang, Teng [1 ]
Jiao, Ning [1 ,2 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 30期
基金：
美国国家科学基金会;
关键词：
alkynes; amides; CC bond cleavage; gold; rearrangement; C-C BOND; QUATERNARY STEREOGENIC CENTERS; CARBON-CYANO BONDS; SCHMIDT REACTION; VINYL AZIDES; MIGRATORY INSERTION; GOLD(I) CATALYSIS; H AMINATION; ARYL AZIDES; ACTIVATION;
D O I：
10.1002/anie.201303376
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Breakthrough: A novel catalyzed direct highly selective C sp 2-C sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2-Csp bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7850 / 7854
页数：5
相关论文
共 129 条
[1]   Carboxylate-Assisted Transition-Metal-Catalyzed C-H Bond Functionalizations: Mechanism and Scope [J].
Ackermann, Lutz .
CHEMICAL REVIEWS, 2011, 111 (03) :1315-1345
[2]   Metal-catalysed approaches to amide bond formation [J].
Allen, C. Liana ;
Williams, Jonathan M. J. .
CHEMICAL SOCIETY REVIEWS, 2011, 40 (07) :3405-3415
[3]  
[Anonymous], 2011, ANGEW CHEM INT ED, V50, P8236
[4]  
[Anonymous], ANGEW CHEM
[5]  
[Anonymous], 2012, ANGEW CHEM INT ED, V51, P12334
[6]  
[Anonymous], 2013, ANGEW CHEM INT ED, V52, P1507
[7]  
[Anonymous], 2000, ANGEW CHEM INT ED, V39, P3070
[8]  
[Anonymous], 2011, ANGEW CHEM INT ED, V50, P5927
[9]  
[Anonymous], 2004, ANGEW CHEM INT ED, V43, P3368
[10]  
[Anonymous], 2008, ANGEW CHEM INT ED, V47, P7040
12345678910