Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition

被引:85
作者
Dudek, SM [1 ]
Friedlander, MJ [1 ]
机构
[1] UNIV ALABAMA,NEUROBIOL RES CTR,BIRMINGHAM,AL 35294
关键词
D O I
10.1016/S0896-6273(00)80136-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
For in vitro LTD to remain viable as a model for synaptic weakening in visual cortical plasticity, it is crucial that it display a critical period for its induction within layer IV. A complicating factor, however, is that LTD in layer IV is modulated by inhibitory postsynaptic potentials (IPSPs); postsynaptic responses characterized as containing IPSPs do not depress in response to 1 Hz afferent stimulation. By blocking IPSPs intracellularly, we find that the ability to induce LTD in layer IV neurons is restored in juvenile, but not in mature animals. This developmental down-regulation of LTD induction is specific for layer IV when compared with LTD induction in layers II/III. These data are consistent with the hypothesis that an LTD-like phenomenon is involved in critical period plasticity and is apparently independent of developmental changes in inhibitory circuitry.
引用
收藏
页码:1097 / 1106
页数:10
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