Use of Anti-Granulocyte Scintigraphy with 99m Tc-Labeled Monoclonal Antibodies for the Diagnosis of Periprosthetic Infection in Patients after Total Joint Arthroplasty: A Diagnostic Meta-Analysis

被引：22

作者：

Xing, Dan ^{[1
,3
]}

Ma, XinLong ^{[1
,2
]}

Ma, JianXiong ^{[2
]}

Wang, Jie ^{[2
]}

Chen, Yang ^{[1
]}

Yang, Yang ^{[1
]}

机构：

[1] Tianjin Hosp, Dept Orthopaed Inst, Tianjin, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Dept Orthopaed, Tianjin, Peoples R China

[3] Tianjin Gongan Hosp, Dept Orthopaed, Tianjin, Peoples R China

来源：

PLOS ONE | 2013年 / 8卷 / 07期

基金：

中国国家自然科学基金;

关键词：

TOTAL KNEE ARTHROPLASTY; WHITE BLOOD-CELL; TOTAL HIP-ARTHROPLASTY; PROSTHESIS INFECTION; SYSTEMATIC REVIEWS; RETROSPECTIVE EVALUATION; LEUKOCYTE SCINTIGRAPHY; ACQUISITION PROTOCOL; CLINICAL-PRACTICE; NUCLEAR-MEDICINE;

D O I：

10.1371/journal.pone.0069857

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The accurate diagnosis of periprosthetic joint infections (PJI) is crucial for therapy and the prevention of complications. No diagnostic test of PJI is 100% accurate. The aim of this study was to assess the use of anti-granulocyte scintigraphy using 99 mTc-labeled monoclonal antibodies to diagnose PJI after total joint arthroplasty. A systematic search of all relevant studies published through January 2013 was conducted using the MEDLINE, EMBASE, OVID, and ScienceDirect databases. Observational studies that assessed the accuracy of the anti-granulocyte scintigraphy with monoclonal antibodies or antibody fragments labeled with technetium 99 m in diagnosis for PJI and provided data on specificity and sensitivity were identified. Standard methods recommended for meta-analysis of diagnostic accuracy were used. Nineteen studies were eligible for inclusion. The results demonstrated that the area under the summary receiver operator curve was 0.88, and the diagnostic accuracy (Q*) was 0.81. Additionally, the diagnostic odds ratio (DOR) was 18.76 with a corresponding 95% confidence interval of 10.45-33.68. The pooled sensitivity and specificity of the diagnostic method for the diagnosis of PJI were 83% and 79%, respectively, while the pooled positive likelihood ratio (PLR) was 3.56, and the negative likelihood ratio (NLR) was 0.26. Anti-granulocyte scintigraphy using 99 mTc-labeled monoclonal antibodies has a reasonable role in the diagnosis of PJI after total joint arthroplasty. Due to the limitations of the present meta-analysis, additional high-quality original studies are required to confirm the predictive value.

引用

页数：14