Isolation and characterization of a novel dithio-carbodenafil analogue from a health supplement

被引：8

作者：

Kee, Chee-Leong ^{[1
]}

Low, Min-Yong ^{[1
]}

Ge, Xiaowei ^{[1
]}

机构：

[1] Hlth Sci Author, Appl Sci Grp, Pharmaceut Lab, 11 Outram Rd, Singapore 169078, Singapore

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2017年 / 137卷

关键词：

3,5-dimethylpiperazinyl; dithio-desmethylcarbodenafil; NMR; Mass Spectrometry; Health supplement; SYNTHETIC PDE-5 INHIBITORS; DIETARY-SUPPLEMENT; STRUCTURE ELUCIDATION; ACETILDENAFIL ANALOG; MASS-SPECTROMETRY; TADALAFIL ANALOG; SILDENAFIL; IDENTIFICATION; FRAGMENTATION;

D O I：

10.1016/j.jpba.2017.01.010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel dithio-carbodenafil compound was isolated and identified from a health supplement. The structure of the unknown compound has been characterized using LC-UV, Fourier Transform Infrared (FTIR), high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. It has been revealed as 3,5-dimethylpiperazinyl dithio-desmethylcarbodenafil as a result of two additional methyl groups on the piperazine ring. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：132 / 138

页数：7

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