The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy

被引:107
作者
Kajihara, Takeshi [1 ]
Brosens, Jan J. [2 ]
Ishihara, Osamu [1 ]
机构
[1] Saitama Med Univ, Dept Obstet & Gynecol, Moroyama, Saitama, Japan
[2] Univ Hosp, Div Reprod Hlth, Warwick Med Sch, Clin Sci Res Labs, Coventry CV2 2DX, W Midlands, England
关键词
Decidualization; Human endometrium; Oxidative stress; FOXO1; Early pregnancy; FORKHEAD TRANSCRIPTION FACTOR; FACTOR-BINDING PROTEIN-1; PLACENTAL OXIDATIVE STRESS; CELL-CYCLE REGULATION; PROGESTERONE-RECEPTOR; STROMAL CELLS; PROLACTIN EXPRESSION; LIGAND EXPRESSION; CROSS-TALK; IN-VITRO;
D O I
10.1007/s00795-013-0018-z
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Successful pregnancy requires coordination of embryo development, decidualization of endometrium, and placenta formation. Decidualization denotes the transformation of endometrial stromal cells into specialized secretory cells, a process further characterized with influx of specialized immune cells into stroma, predominantly uterine natural killer cells and macrophages, and vascular remodeling. This differentiation process depends on the convergence of the cyclic adenosine monophosphate and progesterone signaling pathways. The decidual process is indispensable for the formation of a functional feto-maternal interface as it controls tissue homeostasis during endovascular trophoblast invasion and bestows tissue resistance to environmental stress signals, including protection against oxidative cell death. FOXO proteins have emerged as key mediators of cell fate because of their ability to regulate either pro-apoptotic genes or genes involved in differentiation, cell cycle arrest, oxidative defenses, and DNA repair. In the endometrium, FOXO1 is of particular importance as a critical regulator of progesterone-dependent differentiation, menstrual shedding, and protection of the feto-maternal against oxidative damage during pregnancy.
引用
收藏
页码:61 / 68
页数:8
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