Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

被引：313

作者：

Habrook, Christopher J. ^{[1
]}

Lyssiotis, Costas A. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

CANCER CELL | 2017年 / 31卷 / 01期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE-SPECTROSCOPY; T-CELL IMMUNITY; GLUTAMINE-METABOLISM; IN-VIVO; DUCTAL ADENOCARCINOMA; MR SPECTROSCOPY; MOUSE MODEL; AUTOPHAGY INHIBITION; AEROBIC GLYCOLYSIS;

D O I：

10.1016/j.ccell.2016.12.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.

引用

页码：5 / 19

页数：15

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