Mapping cerebellar degeneration in HIV/AIDS

被引：34

作者：

Klunder, Andrea D. ^{[1
]}

Chiang, Ming-Chang ^{[1
]}

Dutton, Rebecca A. ^{[1
]}

Lee, Sharon E. ^{[1
]}

Toga, Arthur W. ^{[1
]}

Lopez, Oscar L. ^{[2
]}

Aizenstein, Howard J. ^{[3
]}

Becker, James T. ^{[2
,3
,4
]}

Thompson, Paul M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging, Los Angeles, CA 90095 USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

NEUROREPORT | 2008年 / 19卷 / 17期

关键词：

AIDS; cerebellum; computational anatomy; depression; HIV; MRI; morphometry; neurodegeneration; virus;

D O I：

10.1097/WNR.0b013e328311d374

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progressive brain atrophy in HIV/AIDS is associated with impaired psychomotor performance, perhaps partly reflecting cerebellar degeneration; yet little is known about how HIV/AIDS affects the cerebellum. We visualized the three-dimensional profile of atrophy in 19 HIV-positive patients (age: 42.9 +/- 8.3 years) versus 15 healthy controls (age: 38.5 +/- 12.0 years). We localized consistent patterns of subregional atrophy with an image analysis method that automatically deforms each patient's scan, in three dimensions, to match a reference image. Atrophy was greatest in the posterior cerebellar vermis (14.9% deficit) and correlated with depression severity (P=0.009, corrected), but not with dementia, alcohol/substance abuse, CD4+T-cell counts, or viral load. Profound cerebellar deficits in HIV/AIDS (P=0.007, corrected) were associated with depression, suggesting a surrogate disease marker for antiretroviral trials. NeuroReport 19:1655-1659 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：1655 / 1659

页数：5

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