Mapping cerebellar degeneration in HIV/AIDS

被引：34

作者：

Klunder, Andrea D. ^{[1
]}

Chiang, Ming-Chang ^{[1
]}

Dutton, Rebecca A. ^{[1
]}

Lee, Sharon E. ^{[1
]}

Toga, Arthur W. ^{[1
]}

Lopez, Oscar L. ^{[2
]}

Aizenstein, Howard J. ^{[3
]}

Becker, James T. ^{[2
,3
,4
]}

Thompson, Paul M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging, Los Angeles, CA 90095 USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

NEUROREPORT | 2008年 / 19卷 / 17期

关键词：

AIDS; cerebellum; computational anatomy; depression; HIV; MRI; morphometry; neurodegeneration; virus;

D O I：

10.1097/WNR.0b013e328311d374

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progressive brain atrophy in HIV/AIDS is associated with impaired psychomotor performance, perhaps partly reflecting cerebellar degeneration; yet little is known about how HIV/AIDS affects the cerebellum. We visualized the three-dimensional profile of atrophy in 19 HIV-positive patients (age: 42.9 +/- 8.3 years) versus 15 healthy controls (age: 38.5 +/- 12.0 years). We localized consistent patterns of subregional atrophy with an image analysis method that automatically deforms each patient's scan, in three dimensions, to match a reference image. Atrophy was greatest in the posterior cerebellar vermis (14.9% deficit) and correlated with depression severity (P=0.009, corrected), but not with dementia, alcohol/substance abuse, CD4+T-cell counts, or viral load. Profound cerebellar deficits in HIV/AIDS (P=0.007, corrected) were associated with depression, suggesting a surrogate disease marker for antiretroviral trials. NeuroReport 19:1655-1659 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：1655 / 1659

页数：5

共 36 条

[1] Degeneration of the cerebellar dentate nucleus and the inferior olivary nuclei in HIV-1-infected brains: A morphometric analysis [J].

Abe, H ;

Mehraein, P ;

Weis, S .

ACTA NEUROPATHOLOGICA, 1996, 92 (02) :150-155

[2]

[Anonymous], 1992, BRIEF SYMPTOM INVENT

[3] Updated research nosology for HIV-associated neurocognitive disorders [J].

Antinori, A. ;

Arendt, G. ;

Becker, J. T. ;

Brew, B. J. ;

Byrd, D. A. ;

Cherner, M. ;

Clifford, D. B. ;

Cinque, P. ;

Epstein, L. G. ;

Goodkin, K. ;

Gisslen, M. ;

Grant, I. ;

Heaton, R. K. ;

Joseph, J. ;

Marder, K. ;

Marra, C. M. ;

McArthur, J. C. ;

Nunn, M. ;

Price, R. W. ;

Pulliam, L. ;

Robertson, K. R. ;

Sacktor, N. ;

Valcour, V. ;

Wojna, V. E. .

NEUROLOGY, 2007, 69 (18) :1789-1799

[4] Structural correlates of apathy in Alzheimer's disease [J].

Apostolova, Liana G. ;

Akopyan, Gohar G. ;

Partiali, Negar ;

Steiner, Calen A. ;

Dutton, Rebecca A. ;

Hayashi, Kiralee M. ;

Dinov, Ivo D. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

Thompson, Paul M. .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2007, 24 (02) :91-97

[5] Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss [J].

Archibald, SL ;

Masliah, E ;

Fennema-Notestine, C ;

Marcotte, TD ;

Ellis, RJ ;

McCutchan, JA ;

Heaton, RK ;

Grant, I ;

Mallory, M ;

Miller, A ;

Jernigan, TL .

ARCHIVES OF NEUROLOGY, 2004, 61 (03) :369-376

[6]

Becker JT, 2004, AIDS, V18, pS11, DOI 10.1097/00002030-200401001-00003

[7]

Brew BJ, 2004, AIDS, V18, pS75, DOI 10.1097/00002030-200401001-00011

[8] 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry [J].

Chiang, Ming-Chang ;

Dutton, Rebecca A. ;

Hayashi, Kiralee M. ;

Lopez, Oscar L. ;

Aizenstein, Howard J. ;

Toga, Arthur W. ;

Becker, James T. ;

Thompson, Paul M. .

NEUROIMAGE, 2007, 34 (01) :44-60

[9] Longitudinally preserved psychomotor performance in long-term asymptomatic HIV-infected individuals [J].

Cole, M. A. ;

Margolick, J. B. ;

Cox, C. ;

Li, X. ;

Selnes, O. A. ;

Martin, E. M. ;

Becker, J. T. ;

Aronow, H. A. ;

Cohen, B. ;

Sacktor, N. ;

Miller, E. N. .

NEUROLOGY, 2007, 69 (24) :2213-2220

[10] THE NEUROPSYCHIATRIC INVENTORY - COMPREHENSIVE ASSESSMENT OF PSYCHOPATHOLOGY IN DEMENTIA [J].

CUMMINGS, JL ;

MEGA, M ;

GRAY, K ;

ROSENBERGTHOMPSON, S ;

CARUSI, DA ;

GORNBEIN, J .

NEUROLOGY, 1994, 44 (12) :2308-2314

← 1 2 3 4 →