Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

被引：13

作者：

Shrestha, Sanjay ^{[1
]}

Hazelbaker, Mark ^{[1
]}

Yount, Amber L. ^{[2
,3
]}

Walczak, Claire E. ^{[1
]}

机构：

[1] Indiana Univ, Med Sci Program, Bloomington, IN 47405 USA

[2] Indiana Univ, Dept Mol & Cellular Biochem, Bloomington, IN 47405 USA

[3] Franklin Coll, Dept Biol, Franklin, IN 46131 USA

来源：

BIOMOLECULES | 2019年 / 9卷 / 01期

关键词：

microtubule dynamics; mitosis; spindle; molecular motor protein; CYCLE-DEPENDENT CHANGES; PLUS-END; SPINDLE-LENGTH; DYNAMIC INSTABILITY; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; DROSOPHILA KLP67A; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; SPATIAL CONTROL;

D O I：

10.3390/biom9010001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

引用

页数：18

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