Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

被引：13
|
作者：
Shrestha, Sanjay [1 ]
Hazelbaker, Mark [1 ]
Yount, Amber L. [2 ,3 ]
Walczak, Claire E. [1 ]
机构：
[1] Indiana Univ, Med Sci Program, Bloomington, IN 47405 USA
[2] Indiana Univ, Dept Mol & Cellular Biochem, Bloomington, IN 47405 USA
[3] Franklin Coll, Dept Biol, Franklin, IN 46131 USA
来源：
BIOMOLECULES | 2019年 / 9卷 / 01期
关键词：
microtubule dynamics; mitosis; spindle; molecular motor protein; CYCLE-DEPENDENT CHANGES; PLUS-END; SPINDLE-LENGTH; DYNAMIC INSTABILITY; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; DROSOPHILA KLP67A; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; SPATIAL CONTROL;
D O I：
10.3390/biom9010001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.
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页数：18
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