Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: Correlation with E-cadherin

被引:17
作者
Batistatou, Anna [1 ]
Charalabopoulos, Konstantinos [2 ]
Nakanishi, Yukihiro [3 ]
Vagianos, Constantine [4 ]
Hirohashi, Setsuo [3 ]
Agnantis, Niki J. [1 ]
Scopa, Chrissoula D. [5 ]
机构
[1] Univ Ioannina, Sch Med, Dept Pathol, GR-45110 Ioannina, Greece
[2] Univ Ioannina, Sch Med, Dept Physiol, Clin Unit, GR-45110 Ioannina, Greece
[3] Natl Canc Ctr, Res Inst, Div Pathol, Tokyo 104, Japan
[4] Univ Patras, Sch Med, Dept Surg, GR-26110 Patras, Greece
[5] Univ Patras, Sch Med, Dept Pathol, GR-26110 Patras, Greece
关键词
dysadherin; E-cadherin; thyroid; papillary carcinoma; microcarcinoma;
D O I
10.1007/s12022-008-9035-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia.
引用
收藏
页码:197 / 202
页数:6
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