Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase

被引：14
作者：
Li, Lin [1 ,3 ]
Chang, Shenghai [2 ,3 ]
Xiang, Junfeng [1 ]
Li, Qian [1 ,3 ]
Liang, Huanhuan [2 ]
Tang, Yalin [1 ]
Liu, Yingfang [2 ]
机构：
[1] Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, BNLMS,Ctr Mol Sci, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100080, Peoples R China
[3] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
来源：
PLOS ONE | 2012年 / 7卷 / 08期
基金：
中国国家自然科学基金;
关键词：
INFLUENZA-A VIRUSES; PA SUBUNIT; CRYSTAL-STRUCTURE; ACTIVE-SITE; ENDONUCLEASE; INFECTION; AGENTS; STRATEGIES; MUTATION; BINDING;
D O I：
10.1371/journal.pone.0035234
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PAC ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.
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页数：7
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