Bio-medical X-ray imaging with spectroscopic pixel detectors

被引：73

作者：

Butler, A. P. H. ^{[1
,2
,3
,4
]}

Anderson, N. G. ^{[2
,3
]}

Tipples, R. ^{[2
]}

Cook, N. ^{[5
]}

Watts, R. ^{[6
]}

Meyer, J. ^{[6
]}

Bell, A. J. ^{[4
,6
]}

Melzer, T. R. ^{[6
]}

Butler, P. H. ^{[4
,6
]}

机构：

[1] Univ Canterbury, Dept Elect & Comp Engn, Christchurch 1, New Zealand

[2] Canterbury Dist Hlth Board, Dept Radiol, Christchurch, New Zealand

[3] Univ Otago, Sch Med, Christchurch, New Zealand

[4] CERN, Geneva, Switzerland

[5] Canterbury Dist Hlth Board, Dept Med Phys & Bioengn, Christchurch, New Zealand

[6] Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2008年 / 591卷 / 01期

关键词：

medipix; radiography; computed tomography; spectroscopy; X-ray;

D O I：

10.1016/j.nima.2008.03.039

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The aim of this study is to review the clinical potential of spectroscopic X-ray detectors and to undertake a feasibility study using a novel detector in a clinical hospital setting. Detectors currently in development, such as Medipix-3, will have multiple energy thresholds allowing for routine use of spectroscopic bio-medical imaging. We have coined the term MARS (Medipix All Resolution System) for bio-medical images that provide spatial, temporal, and energy information. The full clinical significance of spectroscopic X-ray imaging is difficult to predict but insights can be gained by examining both image reconstruction artifacts and the current uses of dual-energy techniques. This paper reviews the known uses of energy information in vascular imaging and mammography, clinically important fields. It then presents initial results from using Medipix-2, to image human tissues within a clinical radiology department. Detectors currently in development, such as Medipix-3, will have multiple energy thresholds allowing for routine use of spectroscopic bio-medical imaging in the future. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：141 / 146

页数：6

共 23 条

[1] Test of a GaAs-based pixel device for digital mammography [J].

Amendolia, SR ;

Bisogni, MG ;

Bottigli, U ;

Ciocci, MA ;

Delogu, P ;

Dipasquale, G ;

Fantacci, ME ;

Maestro, P ;

Marzulli, V ;

Mikulec, B ;

Pernigotti, E ;

Rosso, V ;

Stefanini, A ;

Stumbo, S .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2001, 460 (01) :50-54

[2]

[Anonymous], 2000, THESIS U VIENNA AUST

[3] BREAST IMAGING - DUAL-ENERGY PROJECTION RADIOGRAPHY WITH DIGITAL RADIOGRAPHY [J].

ASAGA, T ;

CHIYASU, S ;

MASTUDA, S ;

MASTUURA, H ;

KATO, H ;

ISHIDA, M ;

KOMAKI, T .

RADIOLOGY, 1987, 164 (03) :869-870

[4]

BALLABRIGA R, 2006, IEEE P NUCL SCI S OC

[5]

*CERN, 2007, MED 3 COLL WEBS

[6]

Firsching M, 2004, IEEE NUCL SCI CONF R, P4116

[7]

FIRSCHING M, 2004, P IEEE NUCL SCI S C

[8]

Grainger R., 2001, GRAINGER ALLISONS DI, Vfourth

[9] DUAL-ENERGY MAMMOGRAPHY - INITIAL EXPERIMENTAL RESULTS [J].

JOHNS, PC ;

DROST, DJ ;

YAFFE, MJ ;

FENSTER, A .

MEDICAL PHYSICS, 1985, 12 (03) :297-304

[10] X-RAY CHARACTERIZATION OF NORMAL AND NEOPLASTIC BREAST TISSUES [J].

JOHNS, PC ;

YAFFE, MJ .

PHYSICS IN MEDICINE AND BIOLOGY, 1987, 32 (06) :675-695

← 1 2 3 →