Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease

被引：83
作者：
Porrata, LF
Inwards, DJ
Micallef, IN
Ansell, SM
Geyer, SM
Markovic, SN
机构：
[1] Mayo Clin & Mayo Fdn, Dept Internal Med, Div Hematol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Canc Ctr Stat, Biostat Sect, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Med Oncol, Rochester, MN 55905 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 117卷 / 03期
关键词：
absolute lymphocyte count recovery; autologous stem cell transplantation; Hodgkin's disease;
D O I：
10.1046/j.1365-2141.2002.03478.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A retrospective study of 82 patients was conducted to determine the relationship of absolute lymphocyte count (ALC) recovery with clinical outcome after autologous stem cell transplantation (ASCT) in Hodgkin's disease (HD). The median overall (OS) and progression-free survival (PFS) times from the day of transplantation were significantly better for the 41 patients with ALCgreater than or equal to0.5x10(9) cells/l compared with the 41 patients with ALC<0.5x10(9) cells/l ('not yet reached' versus 42 months, P<0.0001; 57 versus 15 months, P<0.002 respectively). Thus, ALC recovery on day 15 post ASCT in HD is associated with better survival and requires further study.
引用
收藏
页码：629 / 633
页数：5
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