Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi

被引：34
作者：
De Souza, E. M.
Menna-Barreto, R.
Araujo-Jorge, T. C.
Kumar, A.
Hu, Q.
Boykin, D. W.
Soeiro, M. N. C.
机构：
[1] Fiocruz MS, DUBC, Lab Biol Celular, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil
[2] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
来源：
PARASITOLOGY | 2006年 / 133卷
关键词：
aromatic diamidines; Trypanosoma cruzi; apoptosis-like death; trypanocidal compounds;
D O I：
10.1017/S0031182006000084
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Two aromatic diamidines, furamidine (DB75) and its phenyl-substituted analogue (DB569), which exhibit trypanocidal activity, were assayed against Trypanosoma cruzi and were found to induce apoptosis-like death characteristics such as nuclear DNA condensation and fragmentation, decreased mitochondrial membrane potential and phosphatidylserine exposure. DB569 displays superior trypanocidal activity compared to furamidine and also had higher ability to induce apoptosis-like death in treated parasites. The present results showing apoptosis-like death in T. cruzi after treatment with both DB75 and DB569 make important contributions to the understanding of the mechanisms of the aromatic diamidines, which represent promising trypaliocidal compounds.
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页码：75 / 79
页数：5
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