Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

被引：16

作者：

Akkerman, S. ^{[1
,3
]}

Blokland, A. ^{[2
,3
]}

Prickaerts, J. ^{[1
,3
]}

机构：

[1] Maastricht Univ, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, Dept Neuropsychol & Psychopharmacol, NL-6200 MD Maastricht, Netherlands

[3] European Grad Sch Neurosci EURON, Maastricht, Netherlands

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2014年 / 109卷

关键词：

Rat; Behavior; Recognition; Memory; Phosphodiesterase; TIME-DEPENDENT IMPROVEMENT; RECOGNITION MEMORY; MOLECULAR MECHANISMS; BASOLATERAL AMYGDALA; TYPE-5; INHIBITORS; CONSOLIDATION; RAT; HIPPOCAMPAL; RETRIEVAL; REACTIVATION;

D O I：

10.1016/j.nlm.2014.01.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We examined the temporal profile of pharmacologically enhanced episodic memory, using the object recognition task. Male Wistar rats were tested at different retention intervals ranging from 1 h to 24 h. The object discrimination performance of all groups (untreated, placebo, drug treatment) gradually decreased up to an interval (8 h). Interestingly, only after this 8 h interval the memory improving effects of vardenafil and rolipram started to emerge. This time-dependent memory performance shows similarities with the Kamin effect. The delayed manifestation of drug-enhanced memory suggests that two separate memory mechanisms are at play, a quick transient form of memory and a more stable memory form that requires several hours to develop. It is important to take this into account when testing treatments intended for long-term memory enhancement. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：139 / 143

页数：5

共 35 条

[31] Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia [J].