Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

被引：16
作者：
Akkerman, S. [1 ,3 ]
Blokland, A. [2 ,3 ]
Prickaerts, J. [1 ,3 ]
机构：
[1] Maastricht Univ, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ, Dept Neuropsychol & Psychopharmacol, NL-6200 MD Maastricht, Netherlands
[3] European Grad Sch Neurosci EURON, Maastricht, Netherlands
来源：
NEUROBIOLOGY OF LEARNING AND MEMORY | 2014年 / 109卷
关键词：
Rat; Behavior; Recognition; Memory; Phosphodiesterase; TIME-DEPENDENT IMPROVEMENT; RECOGNITION MEMORY; MOLECULAR MECHANISMS; BASOLATERAL AMYGDALA; TYPE-5; INHIBITORS; CONSOLIDATION; RAT; HIPPOCAMPAL; RETRIEVAL; REACTIVATION;
D O I：
10.1016/j.nlm.2014.01.006
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
We examined the temporal profile of pharmacologically enhanced episodic memory, using the object recognition task. Male Wistar rats were tested at different retention intervals ranging from 1 h to 24 h. The object discrimination performance of all groups (untreated, placebo, drug treatment) gradually decreased up to an interval (8 h). Interestingly, only after this 8 h interval the memory improving effects of vardenafil and rolipram started to emerge. This time-dependent memory performance shows similarities with the Kamin effect. The delayed manifestation of drug-enhanced memory suggests that two separate memory mechanisms are at play, a quick transient form of memory and a more stable memory form that requires several hours to develop. It is important to take this into account when testing treatments intended for long-term memory enhancement. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：139 / 143
页数：5
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