Radical-Based Synthesis and Modification of Amino Acids

被引：100

作者：

Troyano, Francisco Jose Aguilar ^{[1
]}

Merkens, Kay ^{[1
]}

Anwar, Khadijah ^{[1
]}

Gomez-Suarez, Dr Adrian ^{[1
]}

机构：

[1] Berg Univ Wuppertal, Organ Chem, Gaussstr 20, D-42119 Wuppertal, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 03期

关键词：

amino acids; peptides; photochemistry; radical reactions; synthetic methods; REDOX-ACTIVE ESTERS; C-H FLUORINATION; PHOTOREDOX CATALYSIS; ASYMMETRIC-SYNTHESIS; GAMMA-AMINO; METAL-FREE; DECARBOXYLATIVE ALKYLATION; C(SP(3))-H BONDS; BUILDING-BLOCKS; DERIVATIVES;

D O I：

10.1002/anie.202010157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amino acids (AAs) are key structural motifs with widespread applications in organic synthesis, biochemistry, and material sciences. Recently, with the development of milder and more versatile radical-based procedures, the use of strategies relying on radical chemistry for the synthesis and modification of AAs has gained increased attention, as they allow rapid access to libraries of novel unnatural AAs containing a wide range of structural motifs. In this Minireview, we provide a broad overview of the advancements made in this field during the last decade, focusing on methods for the de novo synthesis of alpha-, beta-, and gamma-AAs, as well as for the selective derivatisation of canonical and non-canonical alpha-AAs.

引用

页码：1098 / 1115

页数：18

共 151 条

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