One-step synthesis of dialkynyl-1,2-diones and their conversion to fused pyrazines bearing enediyne units

被引：58

作者：

Faust, R ^{[1
]}

Weber, C ^{[1
]}

Fiandanese, V ^{[1
]}

Marchese, G ^{[1
]}

Punzi, A ^{[1
]}

机构：

[1] UNIV BARI,DIPARTMENTO CHIM,CNR,CTR STUDIO METODOL INNOVAT SINTESI ORGAN,I-70126 BARI,ITALY

来源：

TETRAHEDRON | 1997年 / 53卷 / 43期

关键词：

D O I：

10.1016/S0040-4020(97)01007-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient procedure for the preparation of symmetrically end-protected dialkynyl-1,2-diones 3 from lithium acetylides and oxalyl chloride in the presence of CuBr and LiBr is described. The condensation of 3 with various aromatic and heteroaromatic 1,2-diamines leads to pyrazine-based alpha-dialkynylated heterocycles. The enediyne substructure of diethynylquinoxaline can be thermally rearranged in a Bergman cyclization reaction. (C) 1997 Elsevier Science Ltd.

引用

页码：14655 / 14670

页数：16

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