Rh catalyzed multicomponent tandem and one-pot reactions under hydroformylation conditions

The hydroformylation reaction represents one of the most important metal catalyzed bulk chemical manufacturing processes today. However, tremendous progress towards more complex molecules using tandem hydroformylation has been achieved during the past decade. Different approaches towards indoles and other nitrogen containing heterocycles, alkaloids, and other biologically active compounds are steadily turning hydroformylation into one of the methods to be considered even in the complex syntheses of natural products and other fine chemicals. The application of organocatalyzed processes coupled with formation of aldehydes through hydroformylation reaction in the synthesis of enantioenriched fine chemicals is another turning point in the application of this reaction. Vast number of other new reaction sequences under hydroformylation conditions have been developed turning tandem and one pot sequences under hydroformylation conditions into a method of choice for organic chemistry and catalysis practitioners. (C) 2015 Elsevier B.V. All rights reserved.