Bis{(E)-3-[(diethylmethylammonio)methyl]-N-[3-(N,N-dimethylsulfamoyl)-1-methylpyridin-4-ylidene]-4-methoxyanilinium} tetraiodide pentahydrate

被引:4
作者
Rodrigues, Tiago [1 ]
Moreira, Rui [1 ]
Dacunha-Marinho, Bruno [2 ]
Lopes, Francisca [1 ]
机构
[1] Univ Lisbon, Fac Pharm, IMed UL, P-1649003 Lisbon, Portugal
[2] Univ Santiago Compostela, Ed CACTUS, Unidade Raios 10, Santiago De Compostela 15782, Spain
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷
关键词
D O I
10.1107/S1600536809000324
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The title compound, 2C(21)H(34)N(4)O(3)S(2+)center dot 4I(-)center dot 5H(2)O, was prepared exclusively as the E isomer by methylation of the corresponding N-phenylpyridin-4-amine. There are two symmetry-independent molecules in the asymmetric unit with no significant differences in bond lengths and angles. The aromatic rings are not coplanar with the pyridin-4-imine groups, as indicated by the C-N-C-C torsion angles of 47.7 (7) and 132.6 (5)degrees.
引用
收藏
页码:O283 / U1828
页数:17
相关论文
共 10 条
[1]   SIR97:: a new tool for crystal structure determination and refinement [J].
Altomare, A ;
Burla, MC ;
Camalli, M ;
Cascarano, GL ;
Giacovazzo, C ;
Guagliardi, A ;
Moliterni, AGG ;
Polidori, G ;
Spagna, R .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119
[2]  
[Anonymous], 2005, APEX2 SAINT
[3]   Public health impact of drug resistant Plasmodium falciparum malaria [J].
Björkman, AB ;
Bhattarai, A .
ACTA TROPICA, 2005, 94 (03) :163-169
[4]   Zwitterionic 6-methyl-2-oxo-3-[1-(ureidoiminio)ethyl]-2H-pyran-4-olate monohydrate [J].
Djedouani, Amel ;
Boufas, Sihem ;
Allain, Magali ;
Bouet, Gilles ;
Khan, Mustayeen .
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 :O1785-U2203
[5]  
Farrugia L. J., 1997, J APPL CRYSTALLOGR, V30, P565, DOI [DOI 10.1107/S0021889897003117, 10.1107/S0021889897003117]
[6]  
Farrugia L. J., 1999, J APPL CRYSTALLOGR, V32, P837, DOI [10.1107/S0021889899006020, 10.1107/S0021889812029111, DOI 10.1107/S0021889812029111]
[7]   Amidomethylation of amodiaquine:: antimalarial N-Mannich base derivatives [J].
Lopes, F ;
Capela, R ;
Gonçaves, JO ;
Horton, PN ;
Hursthouse, MB ;
Iley, J ;
Casimiro, CM ;
Bom, J ;
Moreira, R .
TETRAHEDRON LETTERS, 2004, 45 (41) :7663-7666
[8]   A short history of SHELX [J].
Sheldrick, George M. .
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122
[9]   (S)-1-(2-ammonio-3-methylbutyl)-1,2-dihydropyridin-2-iminiumdibromide [J].
Wang, Yifeng ;
Zhang, Jixv ;
Chen, Hui ;
Luo, Shuping .
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 :O1025-U1717
[10]   Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials [J].
Yeates, Clive L. ;
Batchelor, John F. ;
Capon, Edward C. ;
Cheesman, Neil J. ;
Fry, Mitch ;
Hudson, Alan T. ;
Pudney, Mary ;
Trimming, Helen ;
Woolven, James ;
Bueno, Jose M. ;
Chicharro, Jesus ;
Fernandez, Esther ;
Fiandor, Jose M. ;
Gargallo-Viola, Domingo ;
de las Heras, Federico Gomez ;
Herreros, Esperanza ;
Leon, Maria L. .
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (09) :2845-2852