Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein

被引：17

作者：

Le Buanec, H

Lachgar, A

D'Anna, R

Zagury, JF

Bizzini, B

Bernard, J

Ittelé, D

Hallez, S

Giannouli, C

Burny, A

Zagury, D

机构：

[1] Univ Paris 06, Lab Physiol Cellulaire, F-75005 Paris, France

[2] Inst Jean Godinoi, F-51056 Reims, France

[3] Free Univ Brussels, Dept Biol Mol, Chim Biol Lab, B-1640 Rhode St Genese, Belgium

[4] Inst Jules Bordet, B-1000 Brussels, Belgium

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1999年 / 53卷 / 07期

关键词：

cervical carcinoma; E7; protein; human papillomavirus; HPV-vaccine; immunosuppression;

D O I：

10.1016/S0753-3322(00)88505-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernmatant of SiHa cells, a cervical carcinoma cell line. Extracellular E7 protein, acting as a viral toxin in human immune cells, induces the overproduction of the immune suppressive IFN alpha cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These effects should be taken into account for the design of anti-human cervical carcinoma vaccines. (C) 1999 Elsevier, Paris.

引用

页码：323 / 328

页数：6

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