Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

被引：209
作者：
Chen, Jiang [1 ]
Jin, Renan [1 ]
Zhao, Jie [1 ]
Liu, Jinghua [1 ]
Ying, Hanning [1 ]
Yan, Han [1 ]
Zhou, Senjun [1 ]
Liang, Yuelong [1 ]
Huang, Diyu [1 ]
Liang, Xiao [1 ]
Yu, Hong [1 ]
Lin, Hui [1 ]
Cai, Xiujun [1 ]
机构：
[1] Zhejiang Univ, Dept Gen Surg, Sir Run Run Shaw Hosp, Hangzhou 310003, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2015年 / 367卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Advanced hepatocellular carcinoma (HCC); Epithelial-mesenchymal transitions (EMT) and mesenchymal epithelial transitions (MET); Cancer stem cells (CSCs); Microenvironment; Acquired resistance; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG SIGNALING PATHWAY; ALPHA-B-CRYSTALLIN; LIVER-CANCER CELLS; PHASE-III; PROMOTES METASTASIS; DEPENDENT MECHANISM; PLUS SORAFENIB; BREAST-CANCER; UP-REGULATION;
D O I：
10.1016/j.canlet.2015.06.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sorafenib, an orally-available kinase inhibitor, is the only standard clinical treatment against advanced hepatocellular carcinoma. However, development of resistance to sorafenib has raised concern in recent years due to the high-level heterogeneity of individual response to sorafenib treatment. The resistance mechanism underlying the impaired sensitivity to sorafenib is still elusive though some researchers have made great efforts. Here, we provide a systemic insight into the potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma depending on abundant previous studies and reports. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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页码：1 / 11
页数：11
相关论文
共 168 条
  • [1] Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma A Randomized Trial
    Abou-Alfa, Ghassan K.
    Johnson, Philip
    Knox, Jennifer J.
    Capanu, Marinela
    Davidenko, Irina
    Lacava, Juan
    Leung, Thomas
    Gansukh, Bolorsukh
    Saltz, Leonard B.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (19): : 2154 - 2160
  • [2] Cancer stem cells in solid tumors
    Ailles, Laurie E.
    Weissman, Irving L.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (05) : 460 - 466
  • [3] The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    Angela Nieto, M.
    Cano, Amparo
    [J]. SEMINARS IN CANCER BIOLOGY, 2012, 22 (5-6) : 361 - 368
  • [4] [Anonymous], 2013, GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base
  • [5] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma
    Arao, Tokuzo
    Ueshima, Kazuomi
    Matsumoto, Kazuko
    Nagai, Tomoyuki
    Kimura, Hideharu
    Hagiwara, Satoru
    Sakurai, Toshiharu
    Haji, Seiji
    Kanazawa, Akishige
    Hidaka, Hisashi
    Iso, Yukihiro
    Kubota, Keiichi
    Shimada, Mitsuo
    Utsunomiya, Tohru
    Hirooka, Masashi
    Hiasa, Yoichi
    Toyoki, Yoshikazu
    Hakamada, Kenichi
    Yasui, Kohichiroh
    Kumada, Takashi
    Toyoda, Hidenori
    Sato, Shuichi
    Hisai, Hiroyuki
    Kuzuya, Teiji
    Tsuchiya, Kaoru
    Izumi, Namiki
    Arii, Shigeki
    Nishio, Kazuto
    Kudo, Masatoshi
    [J]. HEPATOLOGY, 2013, 57 (04) : 1407 - 1415
  • [6] Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma
    Bae, Jun Sang
    Noh, Sang Jae
    Kim, Kyoung Min
    Jang, Kyu Yun
    Chung, Myoung Ja
    Kim, Dae Gohn
    Moon, Woo Sung
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (01) : 129 - 136
  • [7] Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway
    Bai, Yongheng
    Lu, Hong
    Wu, Cunzao
    Liang, Yong
    Wang, Silu
    Lin, Chengcheng
    Chen, Bicheng
    Xia, Peng
    [J]. BIOCHEMICAL PHARMACOLOGY, 2014, 92 (03) : 484 - 493
  • [8] The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    Bao, Bin
    Azmi, Asfar S.
    Ali, Shadan
    Ahmad, Aamir
    Li, Yiwei
    Banerjee, Sanjeev
    Kong, Dejuan
    Sarkar, Fazlul H.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02): : 272 - 296
  • [9] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Bao, Shideng
    Wu, Qiulian
    McLendon, Roger E.
    Hao, Yueling
    Shi, Qing
    Hjelmeland, Anita B.
    Dewhirst, Mark W.
    Bigner, Darell D.
    Rich, Jeremy N.
    [J]. NATURE, 2006, 444 (7120) : 756 - 760
  • [10] Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells
    Bareford, M. Danielle
    Park, Margaret A.
    Yacoub, Adly
    Hamed, Hossein A.
    Tang, Yong
    Cruickshanks, Nichola
    Eulitt, Patrick
    Hubbard, Nisan
    Tye, Gary
    Burow, Matthew E.
    Fisher, Paul B.
    Moran, Richard G.
    Nephew, Kenneth P.
    Grant, Steven
    Dent, Paul
    [J]. CANCER RESEARCH, 2011, 71 (14) : 4955 - 4967
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