Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

被引：212

作者：

Chen, Jiang ^{[1
]}

Jin, Renan ^{[1
]}

Zhao, Jie ^{[1
]}

Liu, Jinghua ^{[1
]}

Ying, Hanning ^{[1
]}

Yan, Han ^{[1
]}

Zhou, Senjun ^{[1
]}

Liang, Yuelong ^{[1
]}

Huang, Diyu ^{[1
]}

Liang, Xiao ^{[1
]}

Yu, Hong ^{[1
]}

Lin, Hui ^{[1
]}

Cai, Xiujun ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Gen Surg, Sir Run Run Shaw Hosp, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2015年 / 367卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Advanced hepatocellular carcinoma (HCC); Epithelial-mesenchymal transitions (EMT) and mesenchymal epithelial transitions (MET); Cancer stem cells (CSCs); Microenvironment; Acquired resistance; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG SIGNALING PATHWAY; ALPHA-B-CRYSTALLIN; LIVER-CANCER CELLS; PHASE-III; PROMOTES METASTASIS; DEPENDENT MECHANISM; PLUS SORAFENIB; BREAST-CANCER; UP-REGULATION;

D O I：

10.1016/j.canlet.2015.06.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sorafenib, an orally-available kinase inhibitor, is the only standard clinical treatment against advanced hepatocellular carcinoma. However, development of resistance to sorafenib has raised concern in recent years due to the high-level heterogeneity of individual response to sorafenib treatment. The resistance mechanism underlying the impaired sensitivity to sorafenib is still elusive though some researchers have made great efforts. Here, we provide a systemic insight into the potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma depending on abundant previous studies and reports. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 11

页数：11

共 168 条

[1] Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma A Randomized Trial [J].

Abou-Alfa, Ghassan K. ;

Johnson, Philip ;

Knox, Jennifer J. ;

Capanu, Marinela ;

Davidenko, Irina ;

Lacava, Juan ;

Leung, Thomas ;

Gansukh, Bolorsukh ;

Saltz, Leonard B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (19) :2154-2160

[2] Cancer stem cells in solid tumors [J].

Ailles, Laurie E. ;

Weissman, Irving L. .

CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (05) :460-466

[3] The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity [J].

Angela Nieto, M. ;

Cano, Amparo .

SEMINARS IN CANCER BIOLOGY, 2012, 22 (5-6) :361-368

[4]

[Anonymous], 2013, GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base

[5] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma [J].

Arao, Tokuzo ;

Ueshima, Kazuomi ;

Matsumoto, Kazuko ;

Nagai, Tomoyuki ;

Kimura, Hideharu ;

Hagiwara, Satoru ;

Sakurai, Toshiharu ;

Haji, Seiji ;

Kanazawa, Akishige ;

Hidaka, Hisashi ;

Iso, Yukihiro ;

Kubota, Keiichi ;

Shimada, Mitsuo ;

Utsunomiya, Tohru ;

Hirooka, Masashi ;

Hiasa, Yoichi ;

Toyoki, Yoshikazu ;

Hakamada, Kenichi ;

Yasui, Kohichiroh ;

Kumada, Takashi ;

Toyoda, Hidenori ;

Sato, Shuichi ;

Hisai, Hiroyuki ;

Kuzuya, Teiji ;

Tsuchiya, Kaoru ;

Izumi, Namiki ;

Arii, Shigeki ;

Nishio, Kazuto ;

Kudo, Masatoshi .

HEPATOLOGY, 2013, 57 (04) :1407-1415

[6] Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma [J].

Bae, Jun Sang ;

Noh, Sang Jae ;

Kim, Kyoung Min ;

Jang, Kyu Yun ;

Chung, Myoung Ja ;

Kim, Dae Gohn ;

Moon, Woo Sung .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (01) :129-136

[7] Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway [J].

Bai, Yongheng ;

Lu, Hong ;

Wu, Cunzao ;

Liang, Yong ;

Wang, Silu ;

Lin, Chengcheng ;

Chen, Bicheng ;

Xia, Peng .

BIOCHEMICAL PHARMACOLOGY, 2014, 92 (03) :484-493

[8] The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness [J].

Bao, Bin ;

Azmi, Asfar S. ;

Ali, Shadan ;

Ahmad, Aamir ;

Li, Yiwei ;

Banerjee, Sanjeev ;

Kong, Dejuan ;

Sarkar, Fazlul H. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1826 (02) :272-296

[9] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[10] Sorafenib Enhances Pemetrexed Cytotoxicity through an Autophagy-Dependent Mechanism in Cancer Cells [J].

Bareford, M. Danielle ;

Park, Margaret A. ;

Yacoub, Adly ;

Hamed, Hossein A. ;

Tang, Yong ;

Cruickshanks, Nichola ;

Eulitt, Patrick ;

Hubbard, Nisan ;

Tye, Gary ;

Burow, Matthew E. ;

Fisher, Paul B. ;

Moran, Richard G. ;

Nephew, Kenneth P. ;

Grant, Steven ;

Dent, Paul .

CANCER RESEARCH, 2011, 71 (14) :4955-4967

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