Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons

被引：42

作者：

Ainsbury, Elizabeth ^{[1
]}

Badie, Christophe ^{[1
]}

Barnard, Stephen ^{[1
]}

Manning, Grainne ^{[1
]}

Moquet, Jayne ^{[1
]}

Abend, Michael ^{[2
]}

Antunes, Ana Catarina ^{[3
]}

Barrios, Lleonard ^{[4
]}

Bassinet, Celine ^{[5
]}

Beinke, Christina ^{[6
]}

Bortolin, Emanuela ^{[7
]}

Bossin, Lily ^{[1
,8
]}

Bricknell, Clare ^{[1
]}

Brzoska, Kamil ^{[9
]}

Buraczewska, Iwona ^{[9
]}

Huertas Castano, Carlos ^{[10
]}

Cemusova, Zina ^{[11
]}

Christiansson, Maria ^{[12
]}

Mateos Cordero, Santiago ^{[10
]}

Coster, Guillaume ^{[13
]}

Della Monac, Sara ^{[7
]}

Desangles, Francois ^{[13
]}

Discher, Michael ^{[14
]}

Dominguez, Inmaculada ^{[10
]}

Doucha-Senf, Sven ^{[2
]}

Eakins, Jon ^{[1
]}

Fattibene, Paola ^{[7
]}

Filippi, Silvia ^{[15
]}

Frenzel, Monika ^{[16
]}

Georgieva, Dimka ^{[17
]}

Gregoire, Eric ^{[5
]}

Guogyte, Kamile ^{[18
]}

Hadjidekova, Valeria ^{[17
]}

Hadjiiska, Ljubomira ^{[17
]}

Hristova, Rositsa ^{[17
]}

Karakosta, Maria ^{[19
]}

Kis, Eniko ^{[20
]}

Kriehuber, Ralf ^{[21
]}

Lee, Jungil ^{[22
]}

Lloyd, David ^{[1
]}

Lumniczky, Katalin ^{[20
]}

Lyng, Fiona ^{[23
]}

Macaeva, Ellina ^{[24
,25
]}

Majewski, Matthaeus ^{[2
]}

Vanda Martins, S. ^{[3
]}

McKeever, Stephen W. S. ^{[26
]}

Meade, Aidan ^{[23
]}

Medipally, Dinesh ^{[23
]}

Meschini, Roberta ^{[15
]}

M'kacher, Radhia ^{[16
]}

机构：

[1] Publ Hlth England, Ctr Radiat Chem & Environm Hazards PHE, Chilton, England

[2] BIR, Munich, Germany

[3] Univ Lisbon, Inst Super Tecn IST CTN, Ctr Ciencias & Tecnol Nucl, Bobadela LRS, Lisbon, Portugal

[4] Univ Autonoma Barcelona, Barcelona, Spain

[5] IRSN, Paris, France

[6] Univ Ulm UULM, Bundeswehr Inst Radiobiol, Munich, Germany

[7] Ist Super Sanita, Rome, Italy

[8] Durham Univ DUR, Durham, England

[9] Inst Nucl Chem & Technol, Warsaw, Poland

[10] Univ Seville, Dept Cell Biol, Seville, Spain

[11] SURO, Prague, Czech Republic

[12] Lund Univ, Med Radiat Phys, Malmo, Sweden

[13] IRBA, Paris, France

[14] Salzburg Univ, Dept Geog & Geol, Salzburg, Austria

[15] Univ Tuscia, Viterbo, Italy

[16] Univ Paris Saclay, CEA, Commissariat Energie Atom & Energies Alternat, PROCyTOX, Fontenay Aux Roses, France

[17] NCRRP, Sofia, Bulgaria

[18] RPC, Vilnius, Lithuania

[19] Natl Ctr Sci Res Demokritos, Inst Nucl & Radiol Sci & Technol Energy & Safety, Lab Hlth Phys Radiobiol & Cytogenet, Athens, Greece

[20] Natl Publ Hlth Ctr, NRIRR, Budapest, Hungary

[21] Forschungszentrum Julich, Radiat Biol Unit, Julich, Germany

[22] Korea Atom Energy Res Inst, Daejeon, South Korea

[23] DIT, Dublin, Ireland

[24] Belgian Nucl Res Ctr SCK CEN, Mol, Belgium

[25] Univ Ghent, Ghent, Belgium

[26] Oklahoma State Univ, Stillwater, OK 74078 USA

[27] IIS La Fe, Hlth Res Inst LAFE, Radiat Protect Serv, Valencia, Spain

[28] Hosp Gen Univ Gregorio Maranon SERMAS, Lab Dosimetria Biol, Serv Oncol Radioterap, Madrid, Spain

[29] INSP, Bucharest, Romania

[30] BfS, Dept Radiat Protect & Hlth, Neuherberg, Germany

[31] ENEA Casaccia Res Ctr, Div Hlth Protect Technol, Lab Biosafety & Risk Assessment, Rome, Italy

[32] Leibniz Inst Farm Anim Biol FBN, Dummerstorf, Germany

[33] Univ Milano UNIMI, Milan, Italy

[34] Stockholm Univ, Stockholm, Sweden

[35] Helmholtz Zentrum Munchen HMGU, Neuherberg, Germany

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2017年 / 93卷 / 01期

关键词：

Biodosimetry; physical retrospective dosimetry; radiation accidents; RENEB; PERIPHERAL-BLOOD LYMPHOCYTES; DICENTRIC CHROMOSOMES; IONIZING-RADIATION; GENE-EXPRESSION; IN-VITRO; TRIAGE; SPECTROSCOPY; TELOMERE; NETWORK; TOOL;

D O I：

10.1080/09553002.2016.1206233

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.

引用

页码：99 / 109

页数：11

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